Mineralocorticoid Receptors: Distribution and Activation |
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Authors: | Email author" target="_blank">John?W?FunderEmail author |
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Institution: | (1) Prince Henry s Institute of Medical Research, Clayton 3168, Victoria, Australia;(2) Prince Henry s Institute of Medical Research, P.O. Box 5152, Clayton 3168, Victoria, Australia |
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Abstract: | Mineralocorticoid receptors (MR) bind both mineralocorticoids and glucocorticoids with high affinity (deoxycorticosterone = corticosterone aldosterone = cortisol), and are found in both Na+ transporting epithelia (e.g. kidney, colon) and nonepithelial tissues (e.g. heart, brain). MR evolved before aldosterone synthase, consistent with their acting in nonepithelial tissues as high affinity glucocorticoid receptors, essentially always occupied by normal levels of endogenous glucocorticoids. In epithelial tissues the enzyme 11 hydroxysteroid dehydrogenase Type 2 (11 HSD2) allows aldosterone to selectively activate MR, by converting cortisol to cortisone and NAD to NADH. 11 HSD2 debulks intracellular cortisol by 90%, to levels 10-fold those of aldosterone, so that when the enzyme is operating most epithelial MR are occupied but not activated by cortisol. When intracellular redox state is changed—by inhibition of 11 HSD2, generation of reactive oxygen species, or intracellular introduction of oxidised glutathione (GSSG)—cortisol changes from an MR antagonist to an MR agonist. This bivalent activity of cortisol appears to underlie the therapeutic efficacy of MR blockade in heart failure (RALES, EPHESUS) and in essential hypertension, providing a rationale for MR blockade in cardiovascular disease not characterized by elevated aldosterone levels. Its wider (patho)physiologic implications, particularly for neurobiology, remain to be explored. |
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Keywords: | aldosterone mineralocorticoid receptors 11 " target="_blank">gif" alt="beta" align="MIDDLE" BORDER="0"> hydroxysteroid dehydrogenase vascular inflammation reactive oxygen species NADH redox state |
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