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| 新型酒石酸美托洛尔缓释片的体外释放影响因素 | |
| 引用本文： | 黄蓓琳,吴涓,王洪泉,蔡玉凤,彭应旭. 新型酒石酸美托洛尔缓释片的体外释放影响因素[J]. 中国医院药学杂志, 2001, 21(2): 77-79 |
| 作者姓名： | 黄蓓琳 吴涓 王洪泉 蔡玉凤 彭应旭 |
| 作者单位： | 1. 海同济大学附属同济医院, 2. 上海同济大学附属同济医院, 3. 上海医药工业研究院, |
| 摘 要： | 目的：考察新型酒石酸美托洛尔缓释片（MT）在不同实验条件下的体外释放情况，方法：采用正交试验设计和紫外分光光度法考察MT在不同介质，不同转速及不同方法中的释放度，结果：对MT体外释放影响大小诊次为介质，方法，转速，结论：释放机制均属于偏正转运。 |
| 关 键 词： | 酒后酸美托洛尔 体外释药 紫外分光光度法 缓释片 正交试验 |
| 文章编号： | 1001-5213(2001)02-0077-03 |
| 修稿时间： | 2000-04-07 |
Factor affecting in vitrodrug release of a new metoprolol tartrate extended release tablet |
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| HUANG Bei-Lin,WU Juan,WANG Hong-Quan,et al. Factor affecting in vitrodrug release of a new metoprolol tartrate extended release tablet[J]. Chinese Journal of Hospital Pharmacy, 2001, 21(2): 77-79 | |
| Authors: | HUANG Bei-Lin WU Juan WANG Hong-Quan et al |
| Abstract: | OBJECTIVE:To investigate the drug-release of a new metoprolol tartrate extended release tablet (MT) on different conditions. METHODS:Using orthogonal experiment design, we determined the drug-release of MT with different media, rotate speeds and methods. RESULTS:The biggest affection of drug-release was medium, then method and rotate speed. CONCLUSIONS:The mechanism of drug-release belonged to the anomalous transport. |
| Keywords: | metoprolol tartrate drug-release in vitro UV spectrophotometry |
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