短期胰岛素泵强化治疗对初诊2型糖尿病患者氧化应激的影响

目的探讨短期胰岛素泵强化治疗和多次皮下胰岛素注射对初诊2型糖尿病患者8-异前列腺素F2α和C反应蛋白的影响。方法初诊2型糖尿病患者60例随机分为两组，分别给予胰岛素泵（CSII组）和多次皮下胰岛素注射（MSII组）治疗2周。比较两组治疗前后空腹血糖（FPG）、餐后2h血糖（2hPG）、空腹C肽（FC-P）、餐后2hC肽（2hC-P）、糖化血红蛋白（HbA1C）、血8-异前列腺素F2α、C反应蛋白（CRP）等变化情况。结果MSII组和CSII组治疗后FPG、2hPG、HbAle、8-异前列腺素F2α、CRP均较治疗前明显下降，FC—P、2hC—P均较治疗前明显升高（P〈0．05）。CSII组FPG、2hPG、C-P、2hC-P、8-异前列腺素F2α、CRP治疗前后变化量明显高于MSII组（P〈0．05）。CSII组较MSII组胰岛素用量明显减少（P〈0．05）。结论与多次皮下胰岛素注射组相比，胰岛素泵短期强化治疗不仅具有平稳降糖、改善β细胞功能及胰岛素抵抗的作用，而且具有改善氧化应激及降低炎症的作用。

Effect of short-term insulin pump therapy on oxidative stress in patients with newly diagnosed type 2 diabetes

Objective To investigate the effect of short-term insulin pump therapy and multiple subcutaneous injection of insulin on 8-iso-prostaglandin F2α and C-reactive protein in newly diagnosed type 2 diabetes patients. Methods Sixty patients newly diagnosed with type 2 diabetes were randomly divided into two groups. The patients were given insulin pump therapy in CSII group and multiple subcutaneous injection of insulin in MSII group for 2 weeks. Fasting plasma glucose （FPG）, 2-hour postprandial blood glucose （2 hPG）, fasting C-peptide （C-P） ,2-hour postprandial C-peptide （ 2 hC-P）, glycated hemoglobin （ HbA1c）, blood 8-iso-prostaglandin F2α, C-reactive protein（CRP） and other changes were compared before and after treatment. Results After treatment,FPG,2hPG,HbAlc, 8-iso-prostaglandin F2α, and CRP decreased significantly in two groups （P 〈 0.05 ）, and FC-P,2 hCP were significantly increased （P 〈 0.05 ）. The difference of FPG,2 hPG, CP,2 hC-P,8-iso-prostaglandin F2α, CRP before and after treatment were significantly higher in CSII group than that in MSII group （P 〈 0.05）. The amount of insulin was significantly reduced in CISS group than that in MISS group. Conclusion Compared with multiple subcutaneous injection of insulin, short-term intensive insulin pump therapy not only keep stable blood glucose and improve β-cell function and insulin resistance, but also could improve the oxidative stress and reduce the inflammation.