七氟醚和丙泊酚对老年患者术后认知功能的影响

目的探讨丙泊酚和七氟烷麻醉对老年患者术后认知功能的影响。方法80例60岁以上腹部手术的全身麻醉的老年患者纳入研究，采用抽签法随机分为两组，分别接受丙泊酚（n=40）和异氟烷（n=40）麻醉，比较两组术后简易精神状态量表评分、术后认知功能障碍发生率。结果术后第1天，丙泊酚组的术后认知功能障碍的发生率为27．5％，七氟醚组的发生率为7．5％，两组问有显著性差异（P〈0．05），术后第3天两组患者的认知功能都恢复至术前水平。结论与丙泊酚相比，七氟醚可以减少老年患者全身麻醉术后认知功能障碍的发生。

Effect of propofol and sevoflurane on postoperative cognitive function in the aged patients

Objective To investigate the effect of propofol and sevoflurane on postoperative cognitive function in elderly patients. Methods Eighty elderly patients scheduled for elective upper abdominal surgery under general anesthesia were randomized equally into propofol group and sevoflurane group. Postoperative mini-mental state examination（MMSE） and the rate of postoperative cognitive dysfunetion（POCD） were compared between two groups. Results The incidence of POCD was significantly lower in sevoflurane group than in propofol group at day 1 after surgery （ 7.5 % vs 27.5 %, P 〈 0.05 ）. The cognitive function recovered to the preoperative levels in two groups at day 3 after surgery. Conclusion Compared with propofol, sevoflurane could reduce the incidence of postoperative cognitive dysfunction in the aged patients.