糖尿病肾病相关危险因素分析（英文）

目的：探讨影响糖尿病肾病的相关危险因素。方法：入选明确诊断2型糖尿病患者238例,根据尿微量白蛋白/尿肌酐的比值（UACR）分为糖尿病无肾病组（糖尿病1组,90例）,早期糖尿病肾病组（糖尿病2组,73例）,临床糖尿病肾病组（糖尿病3组,75例）,收集所有患者的临床资料,并检测餐前及餐后2h血糖（FBG、2hPB）,血脂、尿酸（UA）、纤维蛋白原（Fg）、糖化血红蛋白（HbA1c）等生化指标,并分析其与糖尿病肾病的相关性。结果：糖尿病1组、糖尿病2组、糖尿病3组的糖尿病病程[（7.25±6.29）年比（10.25±7.67）年比（13.53±7.82）年]、FBG[（8.46±2.52）mmol/L比（9.52±3.38）mmol/L比（10.82±3.30）mmol/L]、2hPB[（18.40±5.64）mmol/L比（20.27±5.94）mmol/L比（22.59±6.14）mmol/L]、HbA1c[（7.96±1.65）%比（8.60±1.76）%比（9.55±2.09）%]、甘油三酯[（1.72±0.86）mmol/L比（2.34±1.87）mmol/L比（3.16±1.85）mmol/L]、Fg[（3.49±0.93）g/L比（3.88±1.21）g/L比（4.99±2.10）g/L]、UA[（295.42±52.34）μmol/L比（324.18±96.29）μmol/L比（351.23±56.88）μmol/L]水平逐渐显著升高（P〈0.05～〈0.01）。Lo-gistic逐步回归分析显示,糖尿病病程、HbA1c、TG、Fg、UA是糖尿病肾病的危险因素（优势比=1.008～1.910,P〈0.01～〈0.001）。结论：糖尿病病程、血糖、血脂、血尿酸和纤维蛋白原是糖尿病肾病的危险因素;尿微量白蛋白/尿肌酐比值升高反映糖尿病人病情的进展,测定它有助于糖尿病的防治。

Analysis of relative risk factors for diabetic nephropathy

Objective:To study relative risk factors for diabetic nephropathy(DN).Methods:A total of 238 patients diagnosed as type 2 diabetes mellitus(DM) were enrolled in the study.According to urine microalbuminuria to urine creatinine ratio(UACR),patients were divided into pure DM group(group DM1,n=90),early diabetic nephropathy group(group DM2,n=73) and clinical diabetic nephropathy group(group DM3,n=75).Clinic data of all patients were collected;Fasting blood glucose(FBG),2h postprandial blood glucose(2hPB),blood lipids,uric acid(UA),fibrinogen(Fg) and glycosylated haemoglobin(HbA1c) were measured in all patients,and their correlations with DN were analyzed.Results:Compared with group DM1,the course of disease in DM [(7.25±6.29) years vs.(10.25±7.67) years vs.(13.53±7.82) years],levels of FBG [(8.46±2.52) mmol/L vs.(9.52±3.38) mmol/L vs.(10.82±3.30) mmol/L],2hPB [(18.40±5.64) mmol/L vs.(20.27±5.94) mmol/L vs.(22.59±6.14) mmol/L],HbA1c [(7.96±1.65)% vs.(8.60±1.76)% vs.(9.55±2.09)%],triglyceride,Fg [(3.49±0.93) g/L vs.(3.88±1.21) g/L vs.(4.99±2.10) g/L]and UA [(295.42±52.34) μmol/L vs.(324.18±96.29) μmol/L vs.(351.23±56.88) μmol/L]significantly increased in group DM2 and group DM3 in order(P<0.01~<0.001).Logistic gradual regression analysis indicated that course of DM,HbA1c,TG,Fg and UA were risk factors for DN(OR=1.008~1.910,P<0.01~<0.001).Conclusion:The course of DM,blood glucose,blood lipid,uric acid and fibrinogen are risk factors for diabetic nephropathy;increased UACR reflects progress of patients′ condition in DM patients,its detection is used for diabetic prognosis and treatment.