鼻用糠酸莫米松治疗中-重度变应性鼻炎的多中心临床研究

目的 评估鼻用糠酸莫米松喷雾剂治疗变应性鼻炎(allergic rhinitis,AR)患者的临床疗效,以及对患者生活质量的影响.方法 全国10个研究中心完成持续性中-重度AR治疗患者463例,经鼻用糠酸莫米松治疗28 d(200 μg/d),分别于治疗前和治疗后第1、2、4周,对流涕、鼻塞、鼻痒、喷嚏四项临床症状进行评估.同时采用简要鼻结膜炎症生活质量问卷(mini rhinoconjunctivitis quality of life questionnaire,Mini-RQLQ)和鼻结膜炎症夜间生活质量问卷(nocturnal rhinoconjunetivitis quality of life questionnaire,NRQLQ),评估治疗前后患者生活质量和夜间睡眠的变化情况.采用方差分析和符号秩和检验进行统计学处理.结果 与治疗前相比,治疗后第1、2、4周,鼻部各单项症状评分(x±s,下同)呈下降趋势,且后一次访视的评分比前一次访视显著下降(P值均<0.01).治疗前鼻部症状总分为(9.24±1.27)分,治疗后第1周下降到(5.78±2.29)分,第2周和第4周分别下降到(3.99±2.25)分和(2.98±2.14)分,后一次访视的评分比前一次访视评分显著下降(P值均<0.01).同时,与治疗前相比,治疗后第1、2、4周的Mini-RQLQ和NRQLQ各单项评分(x±s,下同)呈下降趋势,且后一次访视的评分比前一次访视的评分显著下降(P值均<0.01).治疗前Mini-RQLQ总均分为(2.88±0.87)分,治疗后第1周下降到(1.89±0.83)分,第2周和第4周分别下降到(1.34±0.82)分和(1.02±0.77)分,后一次访视的评分比前一次访视评分显著下降(P值均<0.01).治疗前NRQLQ总均分为(2.70±0.96)分,治疗后第1周下降到(1.67±0.86)分,第2周和第4周分别下降到(1.17±0.79)分和(0.90±0.75)分,后一次访视的评分比前一次访视评分显著下降(P值均<0.01).结论 鼻用糠酸莫米松喷雾剂治疗4周能够控制持续性中-重度AR患者的临床症状,并能改善患者的生活质量.

Treatment of allergic rhinitis with nasal mometasone furoate

Objective To evaluate the effects of nasal mometasone furoate on moderate to severe allergic rhinitis. Methods Patients with moderate to severe allergic rhinitis were enrolled and received mometasone furoate nasal spray 200 μg once daily for four weeks. Four hundreds and sixty-three patients completed the study. We weekly interviewed the patients to evaluate the symptoms, and the affection of disease on night sleep and daily life. Mini Rhinoconjunctivitis Quality of Life Questionnaire (Mini-RQLQ) and Nocturnal Rhinoconjunctivitis Quality of Life Questionnaire (NRQLQ) were used to evaluate the quality of life. Results The individual and total symptomatic scores of week 1, week 2 and week 4 decreased compared with baseline. The scores of Mini-RQLQ and NRQLQ of week 1, week 2 and week 4 decreased compared with baseline too. The scores of the next visit were significantly lower than those of the previous visit (P < 0. 01 ) . Conclusions A four-week administration of mometasone furoate nasal spray can effectively treat allergic rhinitis.