氟比洛芬酯超前镇痛对髋关节置换术后镇痛效果的影响

目的观察氟比洛芬酯超前镇痛用于髋关节置换术的临床效果。方法将40例52—73岁拟行髋关节置换术病人随机分为两组：A组术前15min静脉缓注氟比洛芬酯1．0mg／kg；B组术前15min静脉缓注等容量生理盐水，每组20例。术毕使用病人自控静脉镇痛（patient controlled intravenous analgesia，PCIA），并采用视觉模拟评分法（visual analogue scale，VAS）分别记录患者术后1h、2h、4h、8h、16h、24h共6个时间点的疼痛评分，记录24h用药量和各种不良反应。结果两组患者的性别、年龄、体重、手术时间、术中出血量等一般情况，无显著性差异（P〉0．05），两组术后的镇痛效果无显著性差异，而A组恶心、呕吐的发生率低于B组（P〈0．05），A组24h内舒芬太尼用药量明显少于B组（P〈0．05）。结论应用氟比洛芬酯超前镇痛能明显减少髋关节置换术患者PCIA期间舒芬太尼用药量及不良反应发生率，提高镇痛质量。

Effect of Flurbiprofen Axetil on Analgesic Efficacy during PCIA with Sufentanil in Patients Follwing Hip Replacement

Objective To observe the preemptive analgesic effect of flurbiprofen axetil on postoperative pain relief.Methods Forty patients following hip replacement under general anesthesia were divided into two groups with 20 cases per each randomly.the patients in groupA received intravenous injection with flurbiprofen axetil 1mg/kg 15 min before surgery,and those in group B intravenous injection with equal volume of saline.Postoperative analgesia efficacy was assessed by visual analoge scales(VAS) at 1h,2h,4h,8h,16h and 24h after surgery.Sufentanil requirements and adverse effects were recorded at 24h after surgery.Results There was no significantly difference in the VAS score between group A and B P>0.05.Nausea and vomiting in group A were significantly less that that in group B P<0.05.Requirements of sufentanil were significantly less in group A than those in group B P<0.05.Conclusion Flubiprofen axetil could produce preemptive effect,save the requirements of sufentanil and reduce the adverse effect.