| 重症肌无力相关细胞因子研究 |
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| 引用本文： | GUO Su-jie,孟和宝力高,E Er-den.重症肌无力相关细胞因子研究[J].医学综述,2008,14(16):2401-2404. |
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| 作者姓名： | GUO Su-jie 孟和宝力高 E Er-den |
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| 作者单位： | 中国人民解放军第二五三医院免疫中心,呼和浩特,010051 |
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| 摘 要： | 重症肌无力及其动物模型——实验性自身免疫性重症肌无力是一种抗体介导,具有细胞免疫依赖的,神经肌肉接头处信号传递障碍的自身免疫性疾病。细胞因子通过复杂的机制参与重症肌无力发病与进展。撰文综述了与重症肌无力有关的几类细胞因子(干扰素、白细胞介素、肿瘤坏死因子、转化生长因子、粒-巨细胞集落刺激因子),并对近年来基于细胞因子和细胞因子传导通路治疗重症肌无力的临床、实验研究进行探讨。
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| 关 键 词： | 重症肌无力 实验性自身免疫性重症肌无力 细胞因子 |
Study of Cytokines Related to Myasthenia Gravis |
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| GUO Su-jie,Meaghe Baoligan,E Er-den.Study of Cytokines Related to Myasthenia Gravis[J].Medical Recapitulate,2008,14(16):2401-2404. |
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| Authors: | GUO Su-jie Meaghe Baoligan E Er-den |
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| Institution: | GUO Su-jie1,2,Menghe Baoligao1,E Er-den1.(1.Center for Immunology,253 Hospital of the Chinese People\'s Liberation Army,Huhhot 010051,China,2.Postgraduate Institute of Inner Mongolia Medical College,Huhhot 010059,China) |
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| Abstract: | Myasthenia gravis （MG） and its animal model, that is experimental autoimmune myasthenia gravis （EAMG）, axe cytoimmunity-dependent ,antibody-mediated autoimmune diseases interfering with signal transmission in the neuromuscular junction. Cytokines is involved in the triggering and development of MG by complicated mechanism. This article not only reviews several cytokines related to myasthenia gravis, such as Interferon （IFN） , Interleukin （IL） , tumor necrosis factor （ TNF ） , Transforming growth factor （ TGF-β ） and Granulocyte macrophage colony stimulating factor （GM-CSF） ,but also debates the clinical and experimental study of the treatment of this disease based on the cytokines and its pathway. |
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| Keywords: | Myasthenia gravis Experimental autoimmune myasthenia gravis(EAMG) Cytokine |
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