DNA ethylations induced by ethylnitrosourea in the wild type, cdc4 and cdc7 strains of Saccharomyces cerevisiae |
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Authors: | Fox, Jayne C. Edwards, Stephen Waters, Raymond |
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Affiliation: | Biomedical and Physiological Research Group, School of Biology, University College of Swansea Singleton Park, Swansea SA2 8PP, UK |
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Abstract: | The experiments reported here have investigated the inductionof ethylations to DNA in yeast cells exposed to the chemicalmutagen ethylnitrosourea. A similar level of alkylation wasseen at the N7 and O6 of guanine and at the N3 of adenine ineither log phase cells or in temperature-sensitive cdc4 andcdc7 cells growth arrested at their specific G1 positions. Hencethe changes in chromosome structure associated with the abovecdc phenotypes do not modify the amount of DNA damage inducedby ethylnitrosourea. 1To whom reprint requests should be addressed |
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