| 阿托品抗脂质过氧化作用及对大鼠脑缺血再灌注损伤的保护作用 |
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| 引用本文： | 吕爱刚,胡香杰.阿托品抗脂质过氧化作用及对大鼠脑缺血再灌注损伤的保护作用[J].河南医学研究,1995,4(3):229-231. |
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| 作者姓名： | 吕爱刚 胡香杰 |
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| 作者单位： | 河南医科大学药理教研室 |
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| 摘 要： | 用阻断四血管方法造成大鼠急性脑缺血再灌注损伤，缺血３０ｍｉｎ，再灌１ｈ，阿托品１ｍｇ／ｋｇ和２ｍｇ／ｋｇ静脉注射可阻止脑组织中超氧化物歧化酶（ＳＯＤ）活性降低，阻止脑组织和外周血中乳酸脱氢酶（ＬＤＨ）活性降低及过氧化脂质的升高（ＬＰＯ），抑制脑水肿形成，促进脑电活动的恢复，阿托品２ｍｇ／ｋｇ静脉注射也可以阻止外周血中ＳＯＤ活性降低，结果提示：阿托品对大鼠急性前脑缺血再灌注损伤具有保护作用，其机制与抗脂质过氧化有关。
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| 关 键 词： | 阿托品，急性脑缺血再灌注损伤，抗脂质过氧化 |
ANTI-LIPID PEROXIDATION AND PROTECTION OF ATROPINE AGAINST CEREBRAL
ISCHEMIA-REPERFUSION INJURIES IN RATS |
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| Lu Ai-gang Hu Xiang-jie Jia Dan-hui et,al.ANTI-LIPID PEROXIDATION AND PROTECTION OF ATROPINE AGAINST CEREBRAL
ISCHEMIA-REPERFUSION INJURIES IN RATS[J].Henan Medical Research,1995,4(3):229-231. |
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| Authors: | Lu Ai-gang Hu Xiang-jie Jia Dan-hui et al |
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| Abstract: | The
ligation of bilateral vertebral and common carotid arteries produced acutecerebral
ischemia-reperfusion injuries in rats. After 30 min ischemia followed 60 min
reperfu-sion,atropine(Atr)at the dose of 1 mg/kg and 2 mg/kg iv may suppress the reduction of
su-peroxide dismutase(SOD)activities in brain tissue and of lactic
dehydrogenase(LDH)activities and decrease the rise of lipid peroxides(LPO)both in brain tissue
and in blood,in-hibit brain edema formation and promote the recovery of EEG activities.The
reduction of su-peroxide dismutase(SOD)activities in blood was also suppressed by Atr at the
dose of 2mg/kg iv.The results suggested that Atr have protective effect on acute forebrain
ischemiaand reperfusion injuries in rats. The underlying mechanism is ascribed partially to the
anti-lipid peroxidation. |
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| Keywords: | atropine acute cerebral ischemia-reperfusion injury anti-lipid peroxidation |
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