2型糖尿病合并骨质疏松症患者血清C肽、骨钙素水平检测

目的：检测2型糖尿病合并骨质疏松症患者血清C肽及骨钙素（ BGP ）水平。方法：收集2013年2月至2014年1月本院老年病科住院治疗的2型糖尿病患者96例，按骨质疏松症诊断标准分为2型糖尿病合并骨质疏松症组（ A组）和单纯2型糖尿病组（ B组）。测定两组患者大转子、股骨颈、Wards区的骨密度，比较两组患者的血清甘油三酯（ TG）、空腹血糖（ FBG）、总胆固醇（ TC）、低密度脂蛋白胆固醇（LDL-C）、高密度脂蛋白胆固醇（HDL-C）、餐后2 h血糖（P2hBG）、空腹C肽、餐后2 h C肽及BGP水平。结果：两组患者血清TG、FBG等生化指标差异均无统计学意义（均P〉0.05）。 A组患者大转子、股骨颈及Wards区骨密度均显著低于B组（均P〈0.05）。 A组患者血清空腹C肽、餐后2 h C肽及BGP水平显著低于B组（均P〈0.05）。结论：血清C肽及BGP可作为2型糖尿病合并骨质疏松症患者筛查的潜在指标。

Expression of proinsulin C-peptide and bone Gla protein in patients with type 2 diabetes mellitus complicated with osteoporosis

Objective：To detect the expression levels of the proinsulin C-peptide and Bone Gla Protein （BGP） in patients with type 2 diabetes mellitus complicated with osteoporosis.Methods：A total of 96 patients with type 2 diabetes mellitus admitted in the Department of Geriatrics of our hospital from February 2013 to January 2014, were divided into type 2 diabetes mellitus complicated with osteoporosis group （ observation group） and simple type 2 diabetes （ control group ） based on the diagnosis criteria of osteoporosis. Bone densities of greater trochanter, femoral neck and Wards area of the two groups were measured. And serum triglyceride （ TG） , fasting blood-glucose （ FBG ） , total cholesterol （ TC ） , low density lipoprotein- cholesterin （ LDL-C ） , high density lipoprotein-cholesterol （ HDL-C ） , postprandial 2h blood glucose （ P2hBG ） , fasting Proinsulin C-peptide, BGP and postprandial 2h Proinsulin C-peptide levels of the two groups were detected. Results： There was no stastical significance between the two groups on TG, FBG and biochemical indicators （P〉0.05）. Bone densities of greater trochanter, femoral neck and Wards area of the observation group were significantly lower than those of the control group （P〈0.05）. Fasting Proinsulin C-peptide, postprandial 2 h Proinsulin C-peptide and BGP were significantly lower than those of the control group （ P〈0.05） . Conclusion：Serum proinsulin C-peptide and BGP can be used as potential index for the screening on patients with type 2 diabetes complicated with osteoporosis.