长托宁和东莨菪碱用作甲状腺手术患者术前用药的比较

目的对比研究甲状腺手术患者术前用长托宁和东莨菪碱的临床效果。方法30例甲状腺手术患者随机分成A、B两组,每组15例,分别在颈丛诱导前半小时肌注长托宁1mg和东莨菪碱0.3mg,记录患者用药前、用药后10min,麻醉前即刻、麻醉后20min的BP、HR、SpO2。结果A组用药后SBP、DBP、HR有下降趋势,麻醉后虽有增高,但与用药前比差异无显著性(P>0.05)。B组用药后SBP、DBP、HR有上升趋势,以麻醉后20min最明显(P<0.01),用药后两组间各时点的SBP、DBP、HR比差异有显著性(P<0.05～0.01)。结论长托宁比东莨菪碱更适合用于甲状腺手术患者术前用药。

Comparison of penehyclidine hydrochloride and scopolamine to thyroid operation as premedication

Objective To compare the effect of penehyclidine hydrochloride and scopolamine to thyroid operation as premedication.Methods group A was injected 1 mg penehyclidine hydrochloride muscularly while group B was injected 0.3 mg scopolamine muscularly.Results SBP,DBP and HR were decreased after injection in the group A.Its were not increase significantly after anesthesia(P>0.05)however,SBP,DBP and HR were increase significantly,especially at 20 min after the cervical plexus block (P<0.01). Conclusion penehyclidine hydrochloride is better than scopolamine to thyroid operation as premedication.