低浓度5-氟尿嘧啶抑制血管增生在瘢痕疙瘩综合治疗中的作用初探

目的 探讨低浓度5-氟尿嘧啶（5-FU）抑制血管增生在瘢痕疙瘩临床综合治疗中的作用。方法 35名瘢痕疙瘩患者，共51个瘢痕疙瘩。平均病史9．7年。以5-Fu2～5mg／ml瘢痕内注射，1次／2周。3～6次后辅以糖皮质激素注射。平均治疗时间为10．29个月。结果 低浓度5-FU抑制瘢痕疙瘩血管增生有效率为96．77％；在治疗6个月以上的患者中，5-FU结合糖皮质激素治疗瘢痕疙瘩的总有效率为97．14％，其中完全缓解者占45．71％，极大缓解者占48．57％，部分缓解者占2．86％．未缓解者占2．86％。结论 利用低浓度5-FU抑制血管增生的作用结合糖皮质激素治疗瘢痕疙瘩具有良好的疗效。

Clinical study on keloid treatment with intralesional injection of low concentration 5-fluorouracil

OBJECTIVE: To explore the effect of intralesional injection of low concentration 5-fluorouracil (5-FU) on inhibition of angiogenesis of keloid. METHODS: 35 patients with 51 keloids were treated with intralesional injection of 5-FU (2-5 mg/ml) biweekly. After 3-6 times of injection, the keloids were treated with intralesional injection of corticosteroid. The average period of treatment was 10.29 months. RESULTS: The efficacy of inhibiting keloid angiogenesis by low concentration of 5-fluorouracil was 96.77%. For the patients who were treated over 6 months with both 5-FU and corticosteroid, the total efficacy was 97.14%. Among them, 45.71% of keloids achieved complete remission, 48.57% mostly remission, 2.86% partial remission and 2.86% no remission. CONCLUSION: Inhibition of keloid angiogenesis with intralesional injection of low concentration of 5-fluorouracil along with corticosteroid injection can achieve satisfactory result.