自身免疫性甲状腺疾病患者血清肿瘤坏死因子的研究

采用放免法检测Graves病（GD）和桥本氏甲状腺炎（HT）患者血清肿瘤坏死因子（TNF）含量。结果显示；GD未治组、GD缓解组和HT组血TNF浓度均显著高于对照组；GD缓解组TNF水平明显低于GD未治组及HT组。提示自身免疫性甲状腺疾病（AITD）患者体内存在细胞因子的异常，TNF的变化可能是AITD发生发展的重要原因。

Detection of Serum Tumor Necrosis Factor in Patients with Graves' Disease and Hashimoto's Thyroiditis

Tumor necrosis factor (TNF) was measured by radioimmunoassay in patients with hyperthyroidism due to Graves' disease (GD) and Hashimoto's thyroiditis (HT). The results showed that the TNF levels in untreated GD and HT patients were significantly higher than that in patients with GD in remission and control subjects. GD patients in remission still had an elevated TNF value as compared to the normal controls. Our results indicate that abnormal cytokine production exists in the patients with autoimmune thyroid diseases (AITD), and TNF may play an important role in the initiation and perpetuation of AITD.