FAB分类慢性淋巴系白血病临床及细胞形态学和生物学特征研究

按1989年FAB对慢性淋巴系白血病分类建议，根据临床、细胞／组织形态学、免疫表型及PCR法IgH与TCRr基因重排分析，血尿免疫球蛋白定量研究，对20例患者（B细胞白血病16例，T细胞白血病4例）进行研究分析。并就B－CLL诊断标准、形态学与生物学特点，疾病的转归，B－PLL、WM及T－LGLL、NK－LGLL的诊断要点进行讨论。对T-白血病／淋巴瘤是否亦应列入分类提出看法，强调了形态学、免疫学及分子遗传学三维诊断对该系统疾病研究的重要性。

The Studies of Chronic Lymphoid Leukemia According to FAB in Clinical Classifiation on Morphology and Biological Characteristics

20 cases of chronic lymphoid leukemia classified following the FAB proposals (1989) were studied.This research was based on clinical features,cell/tissure morphology, immunophenotype, IgH and TCRr gene rearrangement with PCR,and the quantity of serum and urine immunogiubulin. 16 cases of B-lymphoid leukemia(12cases of CLL, 1 case of PLL, 2 cases of leukemia/lymphoma, and 1 case of WM)and 4 cases of T-lymphoid leukemia (2 cases of leukemia/lymphoma, 1 case of LGLL,and 1 case of NK-LGLL)were identified. The diagnostic criteria,morphology,biological characteristics and the prognosis for CLL were discussed,the major diagnostic points for B-PLL,WM,T-LGLL and NK-LGLL were probed. It is suggested that T-leukemia/lymphoma syndrome might beincluded in the field of T-lymphoid leukemia. For the diagnosis of this group of diseases,the importance of mor-phology, immunophenotype together with molecular cytogenetics should be emphasized.