Clinical and histologic evaluations of experimental <Emphasis Type="Italic">Acanthamoeba</Emphasis> keratitis |
| |
| Authors: | Zubeyde Akin Polat Semra Ozcelik Ayse Vural Esin Yıldız Ali Cetin |
| |
| Institution: | (1) CUTFAM Research Center, Cumhuriyet University School of Medicine, 58140 Sivas, Turkey;(2) Department of Parasitology, Cumhuriyet University School of Medicine, 58140 Sivas, Turkey;(3) Department of Ophthalmology, Cumhuriyet University School of Medicine, 58140 Sivas, Turkey;(4) Department of Pathology, Cumhuriyet University School of Medicine, 58140 Sivas, Turkey;(5) Department of Obstetrics and Gynecology, Cumhuriyet University School of Medicine, 58140 Sivas, Turkey |
| |
| Abstract: | Amoebic keratitis, a sight-threatening, progressive corneal disease, is commonly caused by ubiquitous, pathogenic, free-living
Acanthamoeba spp., which are widely distributed in the environment. We investigated clinical findings and histology of Acanthamoeba keratitis in a rat cornea model. Experimental Acanthamoeba keratitis was induced in Wistar rats by intrastromal inoculation of Acanthamoeba castellanii trophozoites. The clinic features of Acanthamoeba keratitis by day 70 are observed. All rats inoculated with Acanthamoeba developed keratitis. Histologically, the eyes displayed blood vessels, edema, and amoebae in stroma. A mixed cellular response,
including neutrophils, mononuclear cells, and spindle-shaped cells, was seen. In conclusion, progressive, suppurative Acanthamoeba keratitis can be induced in the rat cornea model. This rat cornea model assists researchers who study the pathogenesis of
Acanthamoeba keratitis and devise treatment for this difficult condition. |
| |
| Keywords: | |
| 本文献已被 PubMed SpringerLink 等数据库收录！ |
|
