基质金属蛋白酶-9基因C1562T多态性与高血压颈动脉粥样硬化关系

目的:研究基质金属蛋白酶-9(MMP-9)基因C1562T多态性与高血压颈动脉粥样硬化的相关性。方法:原发性高血压患者120例,测定受试者双侧颈动脉内-中膜厚度(IMT),IMT≥1.3mm认为存在粥样硬化斑块。依颈动脉有无粥样硬化分为颈动脉粥样硬化组、颈动脉正常组。用聚合酶链反应-限制性片段长度多态性分析法分析2组患者的MMP-9基因C1562T的多态性。结果:颈动脉粥样硬化组与颈动脉正常组CT TT基因型频率分别为28.8%、13.2%,差异有统计学意义(χ2=4.488,P=0.034),T等位基因与颈动脉粥样硬化发病密切相关(OR=2.092,95%CI:0.991~4.419,P=0.047)。结论:MMP-9T等位基因与高血压颈动脉粥样硬化密切相关,可能是其遗传标志。

Relationship between matrix metalloproteinase-9 polymorphism C1562T and carotid artery arteriosclerosis in patients with essential hypertension

Objective:To investigate the relationship between matrix metalloproteinase-9(MMP-9) polymorphism C1562T and carotid artery arteriosclerosis in patients with essential hypertension (EH).Method:Intimal-medial thickness(IMT) was determined by B ultrasound in 120 patients with EH. Genotype was determined by polymerase chain reaction-restriction fragment length polymorphism for screening C1562T polymorphism of the MMP-9 gene.Result:The results of polymorphisms analysis showed that the frequency of C/T and T/T genotypes of the C1562T polyporphism (28.8%) in hypertension patients with carotid artery arteriosclerosis was significantly higher than that in those who were without carotid artery arteriosclerosis (13.2%). Individuals with EH carrying the -1562T allele had 2-fold higher risk of carotid artery arteriosclerosis (OR:2.092,95% CI:0.991~4.419).Conclusion:Present findings suggest that MMP-9 gene polymorphism (C1562T) may be a risk of carotid artery arteriosclerosis in patients with EH.