| 微囊藻毒素诱导细胞凋亡和促进肿瘤发生的双重作用研究进展 |
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| 引用本文： | 尹建勋,帅怡,仲伟鉴,肖萍.微囊藻毒素诱导细胞凋亡和促进肿瘤发生的双重作用研究进展[J].劳动医学,2010,27(12):756-759. |
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| 作者姓名： | 尹建勋 帅怡 仲伟鉴 肖萍 |
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| 作者单位： | 尹建勋 (复旦大大学公共卫生学院营养与食品卫生教研室,公共卫生安全教育部重点实验室,上海,200032) ； 帅怡 (上海市疾病预防控制中心,上海,200336) ； 仲伟鉴 (上海市疾病预防控制中心,上海,200336) ； 肖萍 (上海市疾病预防控制中心,上海,200336) ； |
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| 基金项目： | 国家自然科学基金,上海市公共卫生优秀青年人才培养计划资助 |
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| 摘 要： | 微囊藻毒素（Microcystin）是世界各地水华中存在最普遍、危害最严重的一类藻类毒素,对环境和人类健康具有极大的危害性。以往研究表明,微囊藻毒素作为一种特异性的肝脏毒素,对细胞内蛋白磷酸酶具有强烈的抑制作用,表现为诱导细胞凋亡和促进肿瘤发生的双重毒性效应。本文简要综述报道微囊藻毒素诱导细胞凋亡和促进肿瘤生成双重毒性作用的研究进展。
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| 关 键 词： | 微囊藻毒素 细胞凋亡 肿瘤促进 |
A Review of the Study on Dualistic Toxicity of Microcystin-induced Apoptosis and Tumor Promotion |
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| YIN Jian-xun,SHUAI Yi,ZHONG Wei-jian,XIAO Ping.A Review of the Study on Dualistic Toxicity of Microcystin-induced Apoptosis and Tumor Promotion[J].Journal of Labour Medicine,2010,27(12):756-759. |
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| Authors: | YIN Jian-xun SHUAI Yi ZHONG Wei-jian XIAO Ping |
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| Institution: | 1.MOE Key Lab of Public Health Safety,Department of Nutrition and Food Hygiene,School of Public Health,Fudan University,Shanghai 200032,China;2.Shanghai Municipal Center for Disease Control and Prevention,Shanghai 200336,China) |
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| Abstract: | Microcystin,as a major blue-green algae toxin in the eutrophic fresh water around the world has been frequently detected,and its hazards to nature and human shouldn＇t be ignored.It has been reported that microcystin,as a specific hepatotoxin,has a strong inhibitory effect on the protein phosphatase,showing the dualistic toxicity with induction of apoptosis and promotion of tumor.In this review,the dualistic toxicity of microcystins was briefly summarized. |
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| Keywords: | microcystin apoptosis tumor promotion |
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