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Potentiation of Metastatic Capacity by Transforming Growth Factor-β1 Gene Transfection |
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| Authors: | Noboru Ueki Toshihisa Ohkawa Yuji Yokoyama Juichiro Maeda Yutaka Kawai Tatsuhiko Ikeda Yoshiki Amuro Toshikazu Hada Kazuya Higashino |
| Affiliation: | The Third Department of Internal Medicine, Hyogo College of Medicine, 1–1 Mukogawa-cho, Nishinomiya, Hyogo 663;Morinaga Institute of Biological Science, 2–1–1 Shimosueyoshi, Tsurumi-ku, Yokohama, Kanagawa 230 |
| Abstract: | This study was designed to assess whether the excessive secretion of transforming growth factor-β1 (TGF-β1) by Chinese hamster ovary (CHO) cells transfected with TGF-β1 gene may be linked to the development of a metastatic phenotype. We observed large numbers of metastatic colonies in the lungs of nude mice inoculated with the transfected CHO cells. The tumors derived from these transfected cells demonstrated marked angiogenesis. We postulate that the overproduction of TGF-β1 by these tumors may participate in the metastatic progression following establishment of angiogenesis at the primary tumor site. |
| Keywords: | Transforming growth factor-βk1 Gene transfer Angiogenesis Lung metastasis |