小剂量米索前列醇用于晚期妊娠引产的效果观察

目的观察２５μｇ米索前列醇对晚期妊娠引产的有效性和安全性。方法选择有引产指征、无引产及米索前列醇使用禁忌证的单胎、头位、胎膜完整的晚期妊娠妇女４８例,随机分为Ａ组（２７例,米索前列醇２５μｇ）和Ｂ组（２１例,米索前列醇５０μｇ）。间隔４～６小时重复给药,２４小时内最大剂量为２００μｇ。胎膜破裂或临产则停止用药。结果Ａ组与Ｂ组引产成功率分别为７７．８％、８１．０％。首次用药至临产时间分别为７６９．９±３５９．９分钟、８０７．４±４０５．２分钟,首次用药至阴道分娩时间分别为９７８．６±４６４．４分钟、９７７．５±４２１．４分钟,加用催产素引产者Ａ组４例、Ｂ组２例;分娩方式、新生儿体重,两组比较,差异均无显著性（Ｐ＞０．０５）,但宫缩过强伴发胎心监护异常的发生率Ａ组低于Ｂ组。结论２５μｇ米索前列醇用于晚期妊娠引产有效而且安全

The effect of 25 micrograms misoprostol on induction of labor in late pregnancy

OBJECTIVE: To determine the efficacy and safety of 25 micrograms misoprostol for labor induction in the third trimester of pregnancy. METHODS: 48 term pregnant women with single pregnant vertex present intact membrane were selected in study group. All case in study group indications for labor induction, without contra-indication of labor induction and misoprostol. The 48 women were randomly assigned A(25 micrograms) and B(50 micrograms) misoprostol groups. Misoprostol was placed in the posterior vaginal fornix every 4 to 6 hours. The maximum dose in 24 hours is 200 micrograms. Misoprostol was not given after either spontaneous rupture of membrane or beginning of active labor. RESULT: The sucesess rate of induction labor was groups 77.8%, 81.0% in group A and B, respectively. The average duration from administration of misoprostol to start of labor in two groups was 796.9 +/- 359.9 minutes and 807.4 +/- 405.2 minutes, respectively; the average duration from start of misoprostol use to vaginal delivery was 978.6 +/- 464.4 minutes, 977.5 +/- 421.4 minutes, respectively. The incidence of vaginal delivery had no statistics significant difference between two groups (P > 0.05). The incidence of hypertonic uterine contraction or hypertonic contractionchysystole with abnormal pattern of fetal monitoring in group A was lower than that of group B, but there was no significant difference (P > 0.05). CONCLUSION: 25 micrograms misoprostol is an efficient and safe dosage for labor induction in term pregnancy.