鲍曼不动杆菌241株的临床分布及耐药性分析

目的了解鲍曼不动杆菌的临床分布及耐药情况,为临床合理使用抗菌药物提供参考依据。方法收集2011年1～12月临床住院患者感染性标本,使用MicroScan WalkAway-40全自动微生物分析仪及MicroScan NegCombo Panel Type31复合板进行细菌学鉴定和药敏试验。结果在241株鲍曼不动杆菌中,痰标本检出率最高为191株(79.3%),其次为伤口分泌物34株(14.1%)。感染科室分布以重症监护病房(ICU)100株(41.5%)及呼吸科45株(18.7%)为主,该菌耐药现象严重,对常用15种抗菌药物耐药率均超过61.0%。结论鲍曼不动杆菌多药耐药现象严重,应加强耐药性监测,了解耐药变迁情况,以指导临床合理用药。

Analysis on clinical distribution and drug resistance in 241 strains of Acinetobacter baumannii

Objective To analyze the distribution and drug resistance in clinical isolates of Acinetobacter bau- mannii to provide evidence for rational drug use in clinic. Methods The clinical infectious specimens from the inpa- tients were collected from January to December 2011 and performed the the bacterial identification and the drug sensi- tivity test by the MicroScan WalkAway-40 fully automatic microorganism analyzer and MicroScan PosComboPane Type31. Results Among 241 strains of Aeinetobacter baumannii,the sputum samples had the highest detection rate （ 191 strains, 79.3 % ）, and followed by the wound secretion samples （34 strains, 14. 1% ）. The infection department distribution was dominated by the intensive care units（ICU, 100 strains, 41.5 M） and the respiration department（45 strains, 18.7 % ）. The drug resistance of this bacterium was serious, the resistance rate to 15 kinds of commonly used antimicrobials was more than 61.0%. Conclusion Multi-drug resistance of Acinetobacter baumannii is serious. Moni- toring of drug resistance should be enhanced and the changes in drug resistance should be understand to guide rational drug use in clinic.