泌尿生殖道支原体4275例培养及药敏结果分析

目的了解该地区泌尿生殖道疾病中支原体感染及常用药物体外药敏状况,为指导临床合理用药提供依据。方法应用珠海丽拓试剂公司提供的支原体鉴定药敏试剂盒对4 275例门诊患者的泌尿生殖道分泌物进行支原体的培养、鉴定及药敏试验,并对12种抗菌药物对支原体的敏感性进行回顾性统计分析。结果 4 275例门诊标本中,支原体检出阳性2 200例,阳性率51.46%,其中男159例,阳性率为31.11%(159/511);女2 041例,阳性率为54.22%(2 041/3 764)。单纯感染解脲脲原体(Uu)阳性1 784例(41.73%),明显高于人型支原体(Mh)阳性18例(0.42%),Uu+Mh混合感染阳性398例(9.31%)。药敏试验显示Uu、Uu+Mh、Mh的耐药性差异有统计学意义,单纯Uu感染者对抗生素的敏感性明显高于混合感染者。交沙霉素、强力霉素、美满霉素对支原体敏感性最高。结论支原体感染以Uu感染为主,女性明显高于男性,不同地区、不同支原体类型和是否混合感染对抗菌药物的敏感性存在差异,临床应根据感染类型及抗菌药物敏感性的不同选择有效的抗生素进行治疗。

Analysis on urogenital tract mycoplasma culture and drug sensitivity results in 4 275 cases

Objective To understand the Mycoplasma infection among genitourinary tract diseases and the in vitro susceptibility of commonly used drugs in local area to provide reference for clinical rational drug use. Methods The culture,identification and the drug sensitivity test of genitourinary tract samples were performed in 4 275 outpa tients by the reagent kit provided by the Zhuhai Lituo reagent company. And the results of 12 kinds of drug sensitivi- ty tests to mycoplasma were analyzed. Results Among 4 275 outpatients samples,2 200 cases were detected positive for Mycoplasma with the positive detection rate of 51.46 %. Among these positive outpatients, 159 cases（31.11%, 159/511） were male and 2 041 cases（54.32%, 2 041/3 764） were female. Among these patients, positive Uu were founded in 1 784 cases（41. 73%）,which was significantly higher than 18 cases（0. 42%） of positive Mh. And the mixed infection by Uu and Mh were 398 cases（9. 31%）. The positive rate of simple Uu infection（1 784 cases, 41.73%） was significantly higher than that of Mh（18 eases,0.42%） and Uu＋Mh（398 eases,9. 31%）. The drug sensitivity test results showed that the drug resistances had certain differences among Uu,Uu＋Mh and Mh. The an- tibiotic sensitivity in simplex Uu infection was higher than that in mixed infection. Josamycin, deoxycycin and mino- cycine were most sensitive to Mycoplasma. Conclusion Mycoplasma infection in genitourinary tract mainly caused by Uu, the positive rate in female patients is predominant. The antibiotic sensitivity in different areas, Mycoplasma types and whether mixed infection has difference. So clinical doctors should select appropriate antibiotics for clinical treat- ment according to differences in infection type and drug sensitivity.