Resistance of Candida albicans biofilms to antifungal agents in vitro. |
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| Authors: | S P Hawser and L J Douglas |
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| Abstract: | Biofilms formed by Candida albicans on small discs of catheter material were resistant to the action of five clinically important antifungal agents as determined by [3H]leucine incorporation and tetrazolium reduction assays. Fluconazole showed the greatest activity, and amphotericin B showed the least activity against biofilm cells. These findings were confirmed by scanning electron microscopy of the biofilms. |
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