41例青年乳腺癌临床病理学特征分析

目的:探讨青年乳腺癌的临床病理学特征。方法:以41例青年乳腺癌患者为试验组,与同期45例中老年患者为对照组,分析比较两组组织学类型、腋窝淋巴结转移、临床分期应用免疫组化SP法检测癌组织中ER、PR、HER-2表达情况等临床病理学特征,并分析比较两组预后。结果:试验组非浸润率占17.07%,与对照组20.00%比较,差异无统计学意义(P>0.05)。腋窝淋巴结转移率实验组80.49%,对照组57.78%,差异具有统计学意义(P<0.05)。ER、PR及HER-2阳性表达率试验组分别为41.46%、39.02%、68.29%,对照组分别为64.44%、66.67%、42.22%比较,差异具有统计学意义(P<0.05)。试验组Ⅰ、Ⅱ期占36.59%、Ⅲ、Ⅳ期占63.41%,对照组分别为64.44%、35.56%,差异具有统计学意义(P<0.05)。比较两组患者生存率,Ⅰ、Ⅱ期差异没有统计学意义(P>0.05);Ⅲ、Ⅳ期试验组均低于对照组,差异具有统计学意义(P<0.05)。结论:青年乳腺癌有不同于中老年患者的临床病理特征,发展快,预后差。

Analysis of clinical pathological features in 41 cases of young breast cancer

Objective To investigate the clinicopathological features of young breast cancer.Method Total 41 cases of young breast cancer in our hospital were as the experimental group,45 cases of elder breast cancer were as the control group at the same period.We compared the histological type,axillary lymph node metastasis,clinical stage and using immune histochemistry SP examines to test the positive expression rates of ER,PR and HER-2 in the two groups.The prognosis of two groups was analyzed and compared.Results The rate of non-invasive tumor in the experimental group was 17.07%,the control group was 20.00%.The difference was not statistically significant(P>0.05).The rate of axillary lymph node metastasis in the experimental group was 80.49%,the controls was 57.78%,the difference was statistically significant(P<0.05).The positive rate of ER,PR and HER-2 in the experimental group was 41.46%,39.02% and 68.29%.The control was 64.44%,66.67% and 42.22%.The difference was statistically significant(P<0.05).The rate of Ⅰ and Ⅱ stage in the experimental group was 36.59%.And the Ⅲ and Ⅳ stage was 63.41%.The control group was 64.44% and 35.56%,respectively.The difference was statistically significant(P<0.05).To compare the survival rate in the two group.The difference in Ⅰ and Ⅱ stage was not statistically significant(P>0.05).The Ⅲ and Ⅳ stage in the experimental group were lower than the control group.The difference was significant(P<0.05).Conclusion The patients of young breast cancer have different clinicopathologic features from the elder patients.The young breast cancer develops fast and has poor prognosis.