热毒宁注射液联合抗菌药物治疗小儿细菌性肺炎的系统评价

目的系统评价热毒宁注射液联合抗菌药物治疗小儿细菌性肺炎的临床疗效。方法检索中国知网中国期刊全文数据库、维普资讯数据库、万方知识数据库,选择热毒宁注射液治疗小儿细菌性肺炎的随机对照试验为研究对象,采用RevMan 5.0软件进行Meta分析。结果共纳入8个研究1 057例患者,Meta分析结果显示,各研究无异质性,热毒宁注射液联合抗菌药物治疗小儿肺炎疗效明显优于对照组OR=4.94,95%CI（2.99,8.17）,P〈0.000 01],不良反应发生率与对照组差异无统计学意义OR=0.83,95%CI（0.46,1.51）,P=0.55]。结论热毒宁注射液联合抗菌抗病毒药物治疗小儿肺炎效果优于单纯抗菌治疗。

A Meta-analysis of Reduning Injection Combined with Antibiotics in the Treatment of Infantile Bacterial Pneumonia

Objective To evaluate the clinical efficacy of Reduning injection combined with antibiotics for infantile bacterial pneumonia. Methods Clinical randomized controlled trials of using Reduning injection combined with antibiotics for infantile bacterial pneumonia retrieved from CNKI Database, VIP Database, and WANFANG Database. RevMan 5.0 software was used for the analysis. Results Eight studies with 1 057 patients were included in the study. The meta-analysis showed no heterogeneity between the studies. In the treatment of infantile pneumonia, Reduning injection combined with antibacterial medicine was significantly better than the control group OR=4.94, 95% CI （2.99, 8.17）, P 〈 0.000 01] and had no significant difference compared with the control group in adverse reaction rate OR=0.83, 95% CI （0.46, 1.51）, P=0.55]. Conclusion Reduning injection combined with antibacterial medicine is more effective in the treatment of infantile pneumonia than simple antibacterial medicine.