健康体检人群外周血炎性细胞的变化与高血压、高血糖及动脉硬化的相关性分析

目的探讨慢性炎症指标与高血压、高血糖和动脉硬化发病的关系。方法选择四川现代医院健康体检部的未曾诊断患有高血压、糖尿病和动脉硬化的体检者3547例,所有体检者晨起8点检测空腹血糖、血压、脉搏波传导速度(ba PWV)和血常规指标。根据检测结果分为正常组、高血压组、高血糖组、动脉硬化组。结果与正常组比较,高血压组的白细胞计数(WBC)、中性粒细胞(NEU)、淋巴细胞(LYM)和中性粒细胞与淋巴细胞比值(NLR)均显著升高,差异有统计学意义(P<0.05)。且年龄、WBC和NLR是体检者罹患高血压的危险因素,而性别为女性是其保护因素。高血糖组的WBC和NEU与正常组比较明显升高,且年龄和WBC是高血糖的危险因素,性别和NLR对血糖的影响差异无统计学意义(P>0.05)。动脉硬化组的WBC、NEU、LYM和NLR与正常组比较差异均无统计学意义(P>0.05),Logistic回归分析显示仅性别和年龄对动脉硬化的发生有影响。结论 WBC与高血压、高血糖的发生密切相关,与动脉硬化的发生无明显影响。而NLR仅与高血压的发病密切相关,可以作为高血压发病的预测因子。

Correlation Analysis of Peripheral Inflammatory Cell Changes in Healthy Population with Hypertension,Hyperglycemia and Atherosclerosis

Objective To investigate the relationship between chronic inflammatory indicators and morbidity of hypertension,hyperglycemia and atherosclerosis.Methods 3547 people who had never been diagnosed hypertension,diabetes mellitus and arteriosclerosis and received physical examination in Sichuan Modern Hospital,were included.Fasting blood-glucose,blood pressure,pulse wave velocity(ba PWV) and blood routine examination were determined in all physical examinees.People were divided into normal group,hypertension group,hyperglycemia group and arteriosclerosis group.Results Compared with normal group,the white blood cell count(WBC),neutrophil(NEU),lymphocyte(LYM) and neutrophil to lymphocyte ratio(NLR) of hypertension group all increased significantly,the difference being statistically significant(P<0.05).Age,WBC and NLR are the risk factors for hypertension,while female gender was a protective factor.WBC and NEU of hyperglycemia group increased significantly,compared with normal group.Age and WBC are risk factors for hyperglycemia,and the difference of blood glucose concentration of people with different gender or NLR was not statistically significant(P>0.05).WBC,NEU,LYM and NLR of atherosclerosis group had no statistically significant difference with normal group(P>0.05),Logistic Regression Analysis showing that only gender and age had an impact on the incidence of atherosclerosis.Conclusion WBC is closely related to the incidence of hypertension and hyperglycemia,but has no significant influence on the incidence of atherosclerosis.NLR is only closely related to the incidence of hypertension and can be used as a predictor of hypertension.