260例治疗失败梅毒患者脑脊液分析

<正>梅毒是由梅毒螺旋体引起的慢性、系统性性传播疾病,临床表现复杂多变,可累及多组织和器官,也可长期处于隐性状态。近年来随着梅毒发病率的升高,经正规驱梅治疗后,临床治疗效果不佳甚至治疗失败的发生率明显升高~1-4]。为探讨梅毒治疗失败

Cerebrospinal fluid (CSF) analysis of 260 syphilis patients with treatment failureYan Yongxing, Yuan Yanrong ,Liang Lizhen,Qu Bin, Liu Jifeng,Qiu Xinming, Zhang Yan,Wu Chunli

Objective: To analyze the characteristics of cerebrospinal fluid (CSF) in the patients with syphilis failed treatment, and to explore the causes of failure. Methods: 260 cases of syphilis patients whose Rapid plasma reaction test (RPR) titer reduced less than four times or rised again after treatment for half a year were received lumbar puncture for cerebrospinal fluid routine, biochemical analysis, IgG index, treponema pallidum particle agglutination(TPPA), venereal disease research laboratory(VDRL) tests and fluorescent treponema antibody absorption assay tests(FTA-ABS) .Results: Among 260 cases of syphilis patients with CSF cytology abnormal 93 cases, 116 cases of abnormal protein, IgG index abnormal 82 cases; there were 22 cases of Symptomatic neurosyphilis and 19 cases of asymptomatic neurosyphilis. Conclusions: Syphilis patients which failed treatment were related with Treponema pallidum infection of the central nervous system, and needed to undergo lumbar puncture for early finding neurosyphilis.