肝动脉栓塞化疗在中晚期原发性肝癌患者中的疗效观察及术后并发症影响因素研究

目的分析并探讨肝动脉栓塞化疗(TACE)治疗中晚期原发性肝癌的临床效果,并对其术后并发症危险因素进行分析,进而更好的降低并发症,提高临床效果。方法选取2012年10月至2015年1月在医院接受治疗的中晚期原发性肝癌160例,随机分为观察组与对照组。观察组采用TACE联合多电极射频(RFA)治疗,对照组采用RFA治疗。结果观察组治疗有效率为93.75%,对照组治疗有效率为81.25%。观察组治疗有效率明显高于对照组。经统计学检验,差异有统计学意义(P<0.05)。观察组术后6个月、12个月、18个月生存率分别为92.50%、86.25%、70.00%。对照组术后6个月、12个月、18个月生存率分别为88.75%、71.25%、50.00%。观察组术后12个月和18个月生存率明显高于对照组(P<0.05)。观察组发热占2.50%,恶心呕吐占3.75%,肝区疼痛占5.00%,感染占17.50%。对照组发热占5.00%,恶心呕吐占3.75%,肝区疼痛占6.25%,感染占16.25%。两组并发症发生率差异无统计学意义(P>0.05)。年龄、腹水、异位栓塞和低蛋白血症是并发症影响因素(P<0.05)。结论 TACE治疗中晚期原发性肝癌的临床效果显著,生存率高,值得推广。

Curative Effect of Transcatheter Hepatic Arterial Chemoembolization on Patients with Advanced Primary Hepatocarcinoma and the Influencing Factors of Postoperative Complications

Objective To study the clinical effect of Transcatheter Hepatic Arterial Chemoembolization( TACE) in the treatment of advanced primary hepatocarcinoma and to analyze the risk factors of postoperative complications,for the purpose of reducing complications and enhancing effectiveness.Methods 160 cases of advanced primary hepatocarcinoma admitted and treated between October 2012 and January 2015 in our hospital were included and randomly divided into observation group and control group.The observation group was treated with TACE combined with multi-electrode radio frequency( RFA),and the control group was treated with RFA.Results The therapeutic response rate of observation group was 93. 75%,significantly higher than 81. 25%of control group,the difference being statistically significant( P<0. 05).The survival rates of patients in observation group 6,12 and18 months after operation were 92. 50%,86. 25% and 70. 00%,respectively. The survival rates of patients in control group 6,12 and 18 months after operations were 88. 75%,71. 25% and 50. 00%,respectively.The survival rates of observation group 12 and 18 months after operation were significantly higher than control group,the difference being statistically significant( P<0. 05).In observation group,the incidence rates were 2. 50% for fever,3. 75% for nausea and vomiting,5. 00% for hepatalgia,17. 50% for infection and in control group,the incidence rates were 5. 00% for fever,3. 75% for nausea and vomiting,6. 25% for hepatalgia,16. 25% for infection.The incidence rates of complications showed no statistically significant difference( P>0. 05) between the two groups.Age,ascites,ectopic embolism and hypoalbuminemia were influencing factors of complications( P<0. 05).Conclusion TACE has significant clinical effect and high survival rate in the treatment of advanced primary hepatocarcinoma,worthy of promotion.