Prophylaxis of regional node metastases with liposomes |
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| Authors: | N. A. Popova V. P. Nikolin V. I. Kaledin |
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| Affiliation: | (1) Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences, Novosibirsk;(2) Novosibirsk State University, Novosibirsk |
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| Abstract: | Experiments on mice showed that local administration of cis-diaminodichloroplatinum incorporated into liposomes inhibited tumor metastases into regional lymph nodes with preserved draining function. When first-order nodes were replaced with tumor tissue, the liposome-incorporated drug inhibited metastasis formation in the second-order lymph nodes (inguinal): it reduced the number and size of metastases in these nodes. Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 127, No. 4, pp. 450–451, April, 1999 |
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| Keywords: | lymph node metastases liposomes cis-diaminodichloroplatinum(II) |
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