祁白芷根中新的天然产物

目的:研究祁白芷根脂溶性化学成分。方法:应用溶剂法和色谱法分离纯化化合物,利用谱学技术鉴定化合物结构。结果:分离得到27个化合物,分别鉴定为异欧前胡素(1)、别异欧前胡素(2)、水合氧化前胡素(3)、比克白芷素(4)、别欧前胡素(5)、β-谷甾醇(6)、邻苯二甲酸二丁酯(7)、7-羟基-6-(3-甲基-2-丁烯氧基)-香豆素(8)、花椒毒酚(9)、5-羟基-8-甲氧基补骨脂素(10)、奥氏芹二醇(11)、伞形花内酯(12)、香柑内酯(13)、欧前胡素(14)、珊瑚菜内酯(15)、异茴芹素(16)、6-乙酰基-7-甲氧基-香豆素(17)、补骨脂素(18)、异东莨菪内酯(19)、滨蒿内酯(20)、花椒毒素(21)、当归醇A(22)、氧化前胡素乙醇醚(23)、去氢柳叶白姜花内酯(24)、尤劳帕替醇(25)、独活属醇(26)、栓翅芹烯醇(27)。结论:化合物8为新的天然产物;除化合物1,3,14外,其余化合物均为首次从祁白芷根中分离得到。

A new natural product from root of Angelica dahurica cv. Qibaizhi

Objective:To study the chemical constituents of the root of Angelica dahurica cv.Qibaizhi.Method: The compounds were isolated and purified by the methods of solvent extraction and chromatographic technique,and their structures were identified on the basis of the analyses of spectral data.Result: Twenty-seven compounds were obtained and identified as isoimperatorin(1),alloisoimperatorin(2),oxypeucedanin hydrate(3),byakangelicin(4),alloimperatorin(5),β-sitosterol(6),dibutylphthalate(7),6-(3,3-dimethylallyloxy)-7-hydroxycoumarin {7-hydroxy-6-(3-methyl-2-butenyl)oxy]-coumarin,8},xanthotoxol(9),5-hydroxy-8-methoxypsoralen(5-hydroxyxanthotoxin,10),smyrindiol(11),umbelliferone(12),bergapten(13),imperatorin(14),phellopterin(15),isoimpinellin(16),6-acyl-7-methoxycoumarin(17),psoralen(18),isoscopletin(19),scoparone(20),xanthotoxin(21),angelol A(22),oxypeucedanin ethanolate(oxypeucedanin hydrate-3″-ethyl ether,23),dehydrogeijerin(pablohopin,24),ulopterol(25),heraclenol(26),and pabulenol(27),respectively.Conclusion:Compound 8 was a new natural product and the above-mentioned all the compounds except for compounds 1,3 and 14 were isolated from the root of A.dahurica cv.Qibaizhi for the first time.