| 醛糖还原酶抑制剂对小鼠胰岛山梨醇代谢的影响 |
| |
| 引用本文： | 李佐强,Naeser Peter,Claes Hellerstr. 醛糖还原酶抑制剂对小鼠胰岛山梨醇代谢的影响[J]. 中华内分泌代谢杂志, 1993, 0(3) |
| |
| 作者姓名： | 李佐强 Naeser Peter Claes Hellerstr |
| |
| 作者单位： | 重庆医科大学附属第一医院内科，重庆医科大学附属第一医院内科，瑞典Uppsala大学医学细胞物系 630042，630042 |
| |
| 摘 要： | 观察了一种醛糖还原酶抑制剂(ICI 128436)对小鼠胰岛体外培养时山梨醇代谢的影响情况。小鼠胰岛培养72小时后,酶抑制剂处理过的胰岛山梨醇水平较对照组显著降低。结果表明小鼠胰岛可以合成山梨醇,其生成水平与醛糖还原酶的活性密切有关。
|
| 关 键 词： | 胰岛 醛糖还原酶抑制剂 山梨醇 |
THE EFFECT OF ALDOSE REDUCTASE INHIBITOR ON THE SORBITOL METABOLISM IN MOUSE PANCREATIC ISLETS CULTURED IN VITRO |
| |
| Li Zuo-qiangDept.of Medicine,The First Affiliated Hospital,Chongqing Medical University. THE EFFECT OF ALDOSE REDUCTASE INHIBITOR ON THE SORBITOL METABOLISM IN MOUSE PANCREATIC ISLETS CULTURED IN VITRO[J]. Chinese Journal of Endocrinology and Metabolism, 1993, 0(3) |
| |
| Authors: | Li Zuo-qiangDept.of Medicine The First Affiliated Hospital Chongqing Medical University |
| |
| Affiliation: | Li Zuo-qiangDept.of Medicine,The First Affiliated Hospital,Chongqing Medical University,630042 |
| |
| Abstract: | The effect of ICI 128436, an aldose reductase inhibitor on the sorbitol metabolism in the mouse pancreatic islets during in vitro culture was observed. After culture for 72 hours, the levels of the sorbitol from the islets treated with the aldose reductase inhibitor were significantly decreased in comparison with those from the control islets. It denotes that the levels of sorbitolgenera-tion are closely related to the activity of aldose reductase, although the sorbitol may be synthctized in the pancreatic islets. |
| |
| Keywords: | Pancreatic islet Aldose reductase inhibitor Sorbitol |
| 本文献已被 CNKI 等数据库收录！ |
