The response of leptin, interleukin-6 and fat oxidation to feeding in weight-losing patients with pancreatic cancer |
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Authors: | Barber M D McMillan D C Wallace A M Ross J A Preston T Fearon K C H |
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Affiliation: | University Department of Surgery, Royal Infirmary, Edinburgh EH3 9YW, UK. |
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Abstract: | At baseline, weight-losing pancreatic cancer patients (n=7) had lower leptin (P<0.05) but higher cortisol, interleukin-6, resting energy expenditure and fat oxidation than healthy subjects (n=6, P<0.05). Over a 4 h feeding period, the areas under the curve for glucose, cortisol and interleukin-6 were greater (P<0.05), but less for leptin in the cancer group (P<0.05). Therefore, it would appear that low leptin concentrations, increased fat oxidation and insulin resistance are associated with increased concentrations of cortisol and interleukin-6 in weight-losing patients with pancreatic cancer. |
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Keywords: | leptin interleukin-6 insulin cortisol fat oxidation feeding weight loss pancreatic cancer |
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