Endoglin gene insertion polymorphism not associated with aneurysmal subarachnoid hemorrhage |
| |
Authors: | Pera Joanna Slowik Agnieszka Dziedzic Tomasz Borratynska Anna Rog Teresa M Betlej Marek Czepko Ryszard Szczudlik Andrzej |
| |
Affiliation: | Department of Neurology, Jagiellonian University, Krakow, Poland. pera@su.krakow.pl |
| |
Abstract: | OBJECT: Data concerning an association between the ENG gene intronic insertion polymorphism and intracrahial aneurysms (IAs) remain inconsistent. In this study the authors investigated whether this polymorphism is associated with a subarachnoid hemorrhage (SAH) caused by a ruptured IA in a Polish population. METHODS: One hundred nineteen patients with aneurysmal SAH and 119 sex-matched healthy volunteers were studied. The insertion ENG gene polymorphism in intron 7 was identified using polymerase chain reaction-single-strand chain polymorphism method. The distribution of the insertion allele did not differ between the SAH (13%) and control (16%) cases (p = 0.36). The homozygous insertion/insertion genotype frequencies in these cases were 3.4 and 0.8%, respectively (p = 0.18). CONCLUSIONS: The authors failed to find an association between the intronic insertion polymorphism of the ENG gene and aneurysmal SAH in a Polish population. |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |
|