Combination therapy: Opportunities and challenges for polymer–drug conjugates as anticancer nanomedicines |
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Authors: | Francesca Greco María J Vicent |
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Institution: | aSchool of Pharmacy, University of Reading, Whiteknights PO BOX 224 Reading RGD6 6AD Berkshire, UK;bCentro de Investigación Príncipe Felipe, Polymer Therapeutics Laboratory, Medicinal Chemistry Dpt., E-46012 Valencia, Spain |
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Abstract: | The discovery of new molecular targets and the subsequent development of novel anticancer agents are opening new possibilities for drug combination therapy as anticancer treatment. Polymer–drug conjugates are well established for the delivery of a single therapeutic agent, but only in very recent years their use has been extended to the delivery of multi-agent therapy. These early studies revealed the therapeutic potential of this application but raised new challenges (namely, drug loading and drugs ratio, characterisation, and development of suitable carriers) that need to be addressed for a successful optimisation of the system towards clinical applications. |
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Keywords: | Polymer-conjugate Polymer therapeutics Nanomedicine Targeted drug delivery Combination therapy Cancer |
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