| 多发性硬化症患者抗糖基化自身髓鞘少突胶质细胞糖蛋白抗体水平升高 |
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| 作者姓名： | Gaertner S. De Graaf K.L. Greve B. Weissert R. 朱光明 |
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| 作者单位： | Department of General Neurology Hertie Inst. for Clin. Brain Res. University of Tbingen H oppe-Seyler-Strasse 3 72076 Tbingen Germany Dr. |
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| 摘 要： | 利用酶联免疫吸附试验(ELISA)测量多发性硬化症(M S)患者及对照者的抗糖基化自身髓鞘少突胶质细胞糖蛋白(M OG)抗体水平。抗M OG IgM抗体在首次脱髓鞘发生时即升高。与缓解患者及健康对照者相比,复发患者及继发慢性进展型M S患者中特异性M O G IgG抗体水平较高。抗自身M O G抗体可能是M S的生物学诊断标记。 Antibodies against native glycosylated myelin-oligodendroc- yte-glycoprotein (MOG) were measured by ELISA in patients with multiple scler osis (MS) and controls. Anti-MOG IgM antibodies were elevat…
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