| 血必净注射液对脓毒症大鼠肝组织凝溶胶蛋白及炎症因子的影响 |
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| 引用本文： | 焦丽娜,姚咏明,寿松涛. 血必净注射液对脓毒症大鼠肝组织凝溶胶蛋白及炎症因子的影响[J]. 解放军医学杂志, 2011, 36(1): 14-16 |
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| 作者姓名： | 焦丽娜 姚咏明 寿松涛 |
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| 作者单位： | 1. 天津医科大学总医院急救中心,天津,300052
2. 解放军总医院第一附属医院全军烧伤研究所,北京,100048 |
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| 基金项目： | 国家重点基础研究发展规划(2005CB522602); 天津市现代中药大品种群系统开发基金(06F22DSH00403) |
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| 摘 要： | 目的 观察中药血必净注射液对脓毒症大鼠肝组织凝溶胶蛋白(GSN)及炎症因子的影响.方法 雄性Wistar大鼠78只,随机分为正常对照组(n=6)、假手术组(n=24)、盲肠结扎穿孔术(CLP)组(n=24)、血必净组(n=24).后两组采用CLP制备脓毒症大鼠模型.假手术组麻醉后开腹翻动盲肠后关腹.血必净组于术后2、1...
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| 关 键 词： | 血必净注射液 脓毒症 钙结合微丝蛋白 内毒素类 HMGB1蛋白 |
Effects of XUEBIJING injection on hepatic gelsolin and inflammatory cytokine in septic rats |
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| JIAO Li-na,YAO Yong-ming,SHOU Song-tao. Effects of XUEBIJING injection on hepatic gelsolin and inflammatory cytokine in septic rats[J]. Medical Journal of Chinese People's Liberation Army, 2011, 36(1): 14-16 |
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| Authors: | JIAO Li-na YAO Yong-ming SHOU Song-tao |
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| Affiliation: | JIAO Li-na,YAO Yong-ming,SHOU Song-tao.Emergency Center,General Hospital of Tianjin Medical University,Tianjin 300052,China |
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| Abstract: | Objective To observe the effects of XUEBIJING injection on the expression of hepatic gelsolin(GSN) and inflammatory cytokine in septic rats.Methods Seventy-eight male Wistar rats were involved in present study and randomly divided into normal control group(n=6),sham operation group(n=24),cecal ligation puncture(CLP) group(n=24) and XUEBIJING group(n=24).The CLP sepsis models of rats were established with the animals in the latter two groups.XUEBIJING injection was injected intravenously at 2,12,24,36,48 and... |
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| Keywords: | XUEBIJING injection sepsis gelsolin endotoxins HMGB1 protein |
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