| 高迁移率族蛋白B1对烫伤大鼠调节性T细胞表型及T细胞功能极化的影响 |
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| 引用本文： | 黄立锋,姚凤华,董宁,张立天,姚咏明.高迁移率族蛋白B1对烫伤大鼠调节性T细胞表型及T细胞功能极化的影响[J].解放军医学杂志,2011,36(1):17-20. |
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| 作者姓名： | 黄立锋 姚凤华 董宁 张立天 姚咏明 |
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| 作者单位： | 解放军总医院第一附属医院全军烧伤研究所,北京,100048 |
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| 基金项目： | 国家自然科学基金(30872683,30901561); 国家重点基础研究发展规划(2005CB522602) |
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| 摘 要： | 目的 探讨严重烫伤延迟复苏后脾脏高迁移率族蛋白B1(HMGB1)表达对调节性T细胞(Treg)表型及其介导T淋巴细胞功能性极化的影响.方法 104只Wistar大鼠随机分为正常对照组(8只)、假烫组(32只)、烫伤组(32只)、丙酮酸乙酯(EP)治疗组(32只).后2组大鼠制作30% TBSA三度烫伤模型,伤后6h腹腔...
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| 关 键 词： | HMGB1蛋白 T淋巴细胞 调节性 叉头转录因子类 烧伤 |
Effects of high mobility group box-1 (HMGB1) protein on phenotype of regulatory T cells and functional polarization of T cells in burned rats |
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| HUANG Li-feng,YAO Feng-hua,DONG Ning,ZHANG Li-tian,YAO Yong-ming.Effects of high mobility group box-1 (HMGB1) protein on phenotype of regulatory T cells and functional polarization of T cells in burned rats[J].Medical Journal of Chinese People's Liberation Army,2011,36(1):17-20. |
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| Authors: | HUANG Li-feng YAO Feng-hua DONG Ning ZHANG Li-tian YAO Yong-ming |
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| Institution: | HUANG Li-feng,YAO Feng-hua,DONG Ning,ZHANG Li-tian,YAO Yong-ming*.Burn Institute,First Hospital Affiliated to General Hospital of PLA,Beijing 100048,China |
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| Abstract: | Objective To explore the effects of high mobility group box-1(HMGB1) protein expression on the phenotype of regulatory T cells(Treg) and the functional polarization of splenic T cells in severe burn rats after delayed resuscitation.Methods One hundred and four Wistar rats were involved in present study and randomly divided into normal control group(n=8),sham burn group(n=32),burn group(n=32) and ethyl pyruvate(EP) treatment group(n=32).Thirty percent TBSA full-thickness burn models were established with the... |
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