Relaxation of carbocyclic thromboxane A2-induced contractions of isolated coronary arteries by nifedipine |
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| Authors: | R. Towart Elisabeth Perzborn |
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| Affiliation: | (1) Institute of Pharmacology, Bayer A.G., D-5600 Wuppertal 1, Germany;(2) Present address: Miles Laboratories Ltd., Stoke Court, SL2 4LY Slough, UK |
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| Abstract: | Summary ± Carbocyclic thromboxame A2 (2.9×10–7 mol/l) contracted isolated rings of cat coronary artery. These contractions could be partly inhibited by low concentrations of nifedipine (50% inhibitory concentration —IC50=6.8×10–8 mol/l) and completely relaxed by papaverine. Relaxation of thromboxane-induced coronary spasm may contribute to the effectiveness of calcium antagonists in variant angina, which may be caused or exacerbated by thromboxane A2 release from platelets. |
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| Keywords: | Calcium antagonists Nifedipine Coronary Spasm Thromboxane A2 Carbocyclic thromboxane A2 |
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