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血脂康对肾病综合征病人脂代谢的影响
引用本文:杨仁勇,徐联芳,王群,於文丽,水华. 血脂康对肾病综合征病人脂代谢的影响[J]. 武汉大学学报(医学版), 2001, 22(1): 55-57
作者姓名:杨仁勇  徐联芳  王群  於文丽  水华
作者单位:武汉大学中南医院肾内科,
摘    要:目的 :研究血脂康对肾病综合征病人脂代谢的调节作用 ,并与辛伐他汀比较。方法 :37例肾病综合征高脂血症病人随机分为血脂康组 (19例 ,血脂康 1.2g/d)和辛伐他汀组 (18例 ,舒降之 10mg/d) ;治疗前和治疗 4周后分别检测肝、肾功能、血脂、电解质及 2 4h尿蛋白。结果 :两组在治疗 4周后TC、TG及LDL C均下降 (P均 <0 .0 1) ,TP、ALB和HDL C升高 (P <0 .0 1或 <0 .0 5 ) ;而两组间比较治疗前和治疗 4周后的上述指标差异均无显著性 (P均>0 .0 5 )。结论 :血脂康能显著性降低肾病综合征病人TC、TG和LDL C水平 ,提高HDL C水平。

关 键 词:高脂血症/治疗  肾变病综合征  脂类/代谢
修稿时间:2000-02-24

The Effect of Xuezhikang on Lipid Metablism in Patients with Nephrotic Syndrome
Yang Ren yong,Xu Lian fang,Wang Qun,et al. The Effect of Xuezhikang on Lipid Metablism in Patients with Nephrotic Syndrome[J]. Medical Journal of Wuhan University, 2001, 22(1): 55-57
Authors:Yang Ren yong  Xu Lian fang  Wang Qun  et al
Affiliation:Yang Ren yong,Xu Lian fang,Wang Qun,et al Department of Nephrology,Zhongnan Hospital,Wuhan University,Wuhan 430071,China
Abstract:Objective:To compare the regulatory effects of Xuezhikang on lipid metabolism with those of Simvastatin in patients with nephrotic syndrome(NS). Methods:37 patients with hyperlipidemia in NS were randomly divided into Xuezhikang group(n=19,Xuezhikang 1.2 g/d, PO) and a control group (n=18,Simvastatin 10 mg/d, PO). The liver and renal function, serum lipid profile and electrolytes were determined before and 4 weeks after the treatment. Results:(1) The effects of lowering total cholesterol (TC), triglyceride (TG) and low density lipoprotein cholesterol(LDL C) were the sameasas those in Simvastatin group 4 weeks after the treatment; the serum total protein, albumine (ALB) and high density lipoprotein cholesterol (HDL C) increased in both groups. (2) The levels of TC, TG, HDL C, TP and ALB before and 4 weeks after the treatment had no significant difference in two groups. Conclusion:Xuezhikang can markedly decrease TC, TG and LDL C concentrations in patients with NS and increase TP, ALB and HDL C concentrations. The effects of Xuezhikang are the same as those of Simvastatin.
Keywords:hyperlipidemia/TH  nephrotic syndrome  lipids/MT
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