| 培哚普利抑制血管合成醛固酮及CYP11B2 mRNA表达 |
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| 引用本文： | 吴平生,梁欣伟,郭志刚. 培哚普利抑制血管合成醛固酮及CYP11B2 mRNA表达[J]. 中华心血管病杂志, 1998, 26(3): 224-225 |
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| 作者姓名： | 吴平生 梁欣伟 郭志刚 |
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| 作者单位： | 第一军医大学附属南方医院心内科 |
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| 摘 要： | 目的 评价血管紧张素转换酶（ＡＣＥ）抑制剂在减轻甚至逆转高血压血管损害中的潜在作用。
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| 关 键 词： | 培哚普利 血管 醛固酮合成 CYP11B2基因 高血压 |
Perindopril inhibits aldosterone biosynthesis and CYP11B2 mRNA expression in vasculature |
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| Wu Pingsheng,Liang Xinwei,Guo Zhigang,et al.. Perindopril inhibits aldosterone biosynthesis and CYP11B2 mRNA expression in vasculature[J]. Chinese Journal of Cardiology, 1998, 26(3): 224-225 |
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| Authors: | Wu Pingsheng Liang Xinwei Guo Zhigang et al. |
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| Affiliation: | Wu Pingsheng,Liang Xinwei,Guo Zhigang,et al. Nanfang Hospital,First Military Medical University,Guangzhou 510515 |
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| Abstract: | Objective To evaluate the potential actions of angiotensin converting enzyme (ACE) inhibitors on blood vessels.Methods By means of ex vivo mesenteric artery perfusion, HPLC and RIA, aldosterone in the perfusate was measured in normal ( n =10) and perindopril (a tissue penetrative ACE inhibitor) treated ( n =10) groups. The expression of aldosterone synthase gene CYP11B2 mRNA in the vessels was determined by RT PCR and Southern blot.Results Perindopril inhibited aldosterone production and CYP11B2 mRNA expression in the blood vessels. Conclusion The inhibition of aldosterone biosynthesis is involved in the remedy of hypertensive vascular damage by perindopril. |
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| Keywords: | perindopril vascular aldosterone CYP11B2 gene ex vivo measenteric artery perfusion |
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