| 褪黑素的神经保护作用 |
| |
| 引用本文： | 李逸玲,刘国卿,龙燕,何玲,季晖.褪黑素的神经保护作用[J].药学进展,2007,31(6):259-263. |
| |
| 作者姓名： | 李逸玲 刘国卿 龙燕 何玲 季晖 |
| |
| 作者单位： | 中国药科大学药理研究室,江苏,南京,210009 |
| |
| 摘 要： | 人体褪黑素是一种主要在松果体合成的激素，具有广泛的生理活性，主要包括调节生物节律，改善睡眠，以及抗氧化、免疫调节、抑制肿瘤等作用。介绍褪黑素的合成、代谢通路及其抗氧化、抗细胞凋亡等神经保护作用。阐述褪黑素的神经保护作用的临床意义。
|
| 关 键 词： | 褪黑素 抗氧化 神经保护 神经退行性病变 |
| 文章编号： | 1001-5094（2007）06-0259-05 |
| 收稿时间： | 2007-03-23 |
| 修稿时间： | 2007-03-23 |
Neuro-protective Effect of Melatonin |
| |
| LI Yi-ling,LIU Guo-qin,LONG Yan,He Ling,JI Hui.Neuro-protective Effect of Melatonin[J].Progress in Pharmaceutical Sciences,2007,31(6):259-263. |
| |
| Authors: | LI Yi-ling LIU Guo-qin LONG Yan He Ling JI Hui |
| |
| Institution: | Division of Pharmacological Research, China Pharmaceutical University, Nanjing 210009, China |
| |
| Abstract: | Human melatonin, a hormone secreted mainly by the pineal gland is one efitieal factor in the correction of biological circadian clock. Additionally, it exerts a wide variety of other biological effects including neutralizing oxidative stress damage, regulating immunity, suppressing tumor growth, and protecting central nerve system. The pathway of synthesis and metabolism, and neuron-protective effect of melatonin were introduced. The clinical significance of melatonin in neurodegenerative disease was also illuminated in this review. |
| |
| Keywords: | Melatonin Antioxidation Neural protection Neurodegenerative disease |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
|
