| 先声咳喘灵口服液对哮喘大鼠作用机制研究 |
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| 引用本文： | 钱 正,陶宜富,张 倩,杨 俭.先声咳喘灵口服液对哮喘大鼠作用机制研究[J].南京医科大学学报,2010(12):1781-1783. |
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| 作者姓名： | 钱 正 陶宜富 张 倩 杨 俭 |
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| 作者单位： | 南京医科大学基础医学院药理学系,江苏 南京 210029;南京医科大学附属南京第一医院药学部,江苏 南京 210006;南京医科大学附属南京第一医院药学部,江苏 南京 210006;南京医科大学基础医学院药理学系,江苏 南京 210029 |
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| 基金项目： | 国家自然科学基金（30070881）；江苏省教育厅自然科学基金（03KJB310079)资助 |
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| 摘 要： | 目的: 研究先声咳喘灵口服液对哮喘模型大鼠抗哮喘作用的机制?方法:60只健康大鼠随机分为对照组?模型组?治疗组,每组20只?建立由卵蛋白致敏并诱发的支气管哮喘模型(40只),其中治疗组连续7天使用先声咳喘灵口服液(10 ml/kg)灌胃治疗?并采用ELISA法检测大鼠血清中细胞因子白介素(IL)-4?IL-5?IL-13的含量?结果:治疗组大鼠哮喘症状有明显改善,与哮喘组相比治疗组大鼠血清中IL-4?IL-5?IL-13的含量明显下降?结论:抑制细胞因子IL-4?IL-5及IL-13的合成可能为先声咳喘灵口服液抗哮喘的作用机制之一?
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| 关 键 词： | 先声咳喘灵口服液 哮喘模型 IL-4 IL-5 IL-13 |
Anti-asthma mechanism of Xiansheng Kechuanling oral liquid in asthma rat model |
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| QIAN Zheng,TAO Yi-fu,ZHANG Qian and YANG Jian.Anti-asthma mechanism of Xiansheng Kechuanling oral liquid in asthma rat model[J].Acta Universitatis Medicinalis Nanjing,2010(12):1781-1783. |
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| Authors: | QIAN Zheng TAO Yi-fu ZHANG Qian and YANG Jian |
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| Institution: | Department of Pharmacy,School of Basic Medical science, NJMU, Nanjing 210029;Nanjing First Hospital Affiliated with NJMU, Nanjing 210006, China;Nanjing First Hospital Affiliated with NJMU, Nanjing 210006, China;Department of Pharmacy,School of Basic Medical science, NJMU, Nanjing 210029 |
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| Abstract: | Objective: To investigate possible anti-asthma mechanisms of Xiansheng kechuanling Oral Liquid in asthma model rats.Methods:Sixty rats were randomly divided into normal control group, asthmatic model group and treatment group with 20 rats in each group. Rat asthma model were established by egg albumin induction. The rats of treatment group were treated with Xiansheng kechuanling Oral Liquid (10 ml/kg) once daily for 7 days continuously. The concentrations of IL-4, IL-5 and IL-13 in rat plasma were determined using ELISA. Results:The symptom of asthma in treatment group was more improved than that in model group. Furthermore, the concentrations of IL-4, IL-5 and IL-13 in plasma were significantly decreased in treatment group than those in model group. Conclusion:These findings suggest that Xiansheng kechuanling Oral Liquid inhibits IL-4, IL-5 and IL-13, which is likely to be one of its anti-asthma mechanisms. |
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| Keywords: | Xiansheng kechuanling oral liquid asthma model IL-4 IL-5 IL-13 |
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