OTR、ER在子宫腺肌病中的表达及与痛经的关系

目的:探讨OTR、ER在子宫腺肌病患者在位及病灶组织中的表达及其与痛经的关系。方法:采用免疫组化法检测30例子宫腺肌病在位和异位内膜中OTR、ER的表达,以子宫正常肌层组织和在位内膜为对照。结果:在子宫腺肌病灶组织中OTR、ER的表达高于在位内膜组及对照组(P<0.05);在子宫腺肌病组的在位内膜和病灶组织中,痛经组OTR、ER的表达高于无痛经组及对照组(P<0.05);在不同痛经程度分组中OTR、ER的表达依次降低。在子宫腺肌病的在位内膜和病灶组织中,OTR、ER两者之间存在正相关关系。结论:子宫腺肌病组织中OTR、ER的表达随痛经程度增强而增加,在子宫腺肌病痛经的发生与发展间可能存在协同作用。

Expressions of oxytocin receptor and estrogen receptor in adenomyosis and their relationships with dysmenorrhea

Objective:To explore the expression levels of oxytocin receptor and estrogen receptor in eutopic endometrium and ectopic endometrium of the patients with adenomyosis and their relationships with dysmenorrhea. Methods:Immunohistochemical staining was used to detect the expression levels of oxytocin receptor and estrogen receptor in eutopic endometrium and ectopic endometrium of 30 patients with adenomyosis,normal uterine muscular tissue and eutopic endometrium were designed as control group. Results:The expression levels of oxytocin receptor and estrogen receptor in ectopic endometrium of adenomyosis group were significantly higher than those in eutopic endometrium of adenomyosis group and control group(P<0.05);in eutopic endometrium and ectopic endometrium of adenomyosis group,the expression levels of oxytocin receptor and estrogen receptor in dysmenorrhea subgroup were significantly higher than those in non-dysmenorrhea subgroup(P<0.05);the expression levels of oxytocin receptor and estrogen receptor decreased sequently in the subgroups with different degrees of dysmenorrhea;in eutopic endometrium and ectopic endometrium of adenomyosis group,there was a positive correlation between oxytocin receptor and estrogen receptor. Conclusion:The expression levels of oxytocin receptor and estrogen receptor increased with the increase of degree of dysmenorrhea among the patients with adenomyosis,which may play synergistic effects in the occurrence and development of adenomyosis.