胎粪吸入综合征的临床分析和预后相关因素研究

目的:探讨不同治疗方法对胎粪吸入综合征(MAS)的疗效以及患者预后分析。方法:选择该院2005～2009年收治的胎粪吸入综合征患者70例,随机分为治疗组和对照组,治疗组行机械通气以及肺表面活性物质(PS)进行治疗,对照组行机械通气以及常规治疗。治疗中对各组患者的病程、预后以及肺氧合功能进行评价。结果:两组患者在治疗后与治疗前在氧合指数的比较中治疗组优于对照组(P<0.05),在对相关分子的研究中,治疗后治疗组患者的相关指标要优于对照组(P<0.05),在并发症的比较中治疗组较对照组少。结论:机械通气联合PS可明显提高MAS的疗效,并降低其并发症,提高患儿的预后。

Study on meconium aspiration syndrome and related factors of prognosis

Objective:To explore the curative effects of different therapeutic methods for meconium aspiration syndrome(MAS),analyze the prognosis of the patients. Methods:Seventy patients with MAS who were treated in the hospital from 2005 to 2009 were selected,then they were divided into treatment group and control group randomly,the patients in treatment group were treated with mechanical ventilation and pulmonary surfactant,while the patients in control group were treated with mechanical ventilation and conventional treatment.The course of the disease,prognosis,and pulmonary oxygenation of the patients in the two groups were evaluated. Results:The oxygenation indexes before and after treatment in treatment group were significantly higher than those in control group(P<0.05);after treatment,the related indexes in treatment group were better than those in control group(P<0.05);the complications in treatment group were less than those in control group. Conclusion:Mechanical ventilation combined with pulmonary surfactant can improve the curative effect in treatment of MAS,reduce complications,and improve the prognosis of the patients.