血清SccAg、CA125、CA19-9在宫颈癌及癌前病变中的表达及意义

目的:研究鳞状上皮细胞癌抗原(SccAg)、癌抗原125(CA125)、癌抗原19-9(CA19-9)在癌前病变及宫颈癌中的表达和意义。方法:检测正常对照组血清34例、宫颈上皮内瘤变(CIN)组126例、宫颈癌组57例,对不同临床分期、分化程度和病理类型宫颈癌的三种肿瘤标志物进行比较。结果:SccAg在宫颈癌前病变已有变化,CA125和CA19-9变化不明显,血清中SccAg的水平与肿瘤临床分期、肿瘤病理分级、淋巴结转移呈正相关,CA125和CA19-9在检测腺癌中更有应用价值。结论:综合分析宫颈癌患者的肿瘤标志物能为患者的辅助诊断、病情诊治、预后提供指导信息。

Expressions and significances of serum SccAg,CA125,and CA19-9 in cervical cancer and cervical precancerous lesion

Objective:To study the expressions and significances of serum squamous cell carcinoma antigen(SccAg),cancer antigen 125(CA125),carbohydrate antigen 19-9(CA19-9) in cervical cancer and cervical precancerous lesion.Methods:Thirty-four serum samples in normal control group,one hundred and twenty-six serum samples in cervical intraepithelial neoplasia(CIN) group,and fifty-seven serum samples in cervical cancer group were detected,the three tumor markers in cervical cancer of different clinical stages,differentiation degrees,and pathological types were compared.Results:Serum SccAg expression changed in cervical precancerous lesion,the changes of CA125 and CA19-9 were not obvious.There was a positive correlation between serum SccAg level and clinical stages,pathological degrees,and lymph node metastasis of cervical cancer,CA125 and CA19-9 had great application values in detection of cervical adenocarcinoma.Conclusion:Comprehensively analyzing tumor markers can provide guidance and data for assisted diagnosis,diagnosis,treatment,and prognosis of the patients with cervical cancer.