影响宫腔内人工授精临床妊娠结局的相关因素

目的:通过对宫腔内人工授精(IUI)临床资料的回顾性分析,探讨男性因素与IUI妊娠结局的关系。方法:回顾性分析2010年1～12月在河南省人民医院生殖医学中心进行的329个IUI治疗周期的临床资料。按照IUI结局分为妊娠组、非妊娠组,比较各组患者在男方年龄、女方年龄、不孕病史、精子参数等方面的差异。分别按照男方年龄、女方年龄、不孕年限、精子参数等指标进行分组,比较各组患者妊娠率的差异。结果:妊娠组和非妊娠组的男女双方年龄、不孕年限等指标差异均无统计学意义(P>0.05);女方年龄>35岁组临床妊娠率低于≤35岁组(P<0.05),处理后前向运动精子数<2×106条组临床妊娠率低于处理后前向运动精子数≥2×106条组(P<0.05),其余各组临床妊娠率差异无统计学意义(P>0.05)。结论:在输卵管通畅的情况下,处理后前向运动精子数≥2×106条男性不育者应尽可能采用IUI进行治疗,处理后前向运动精子数<2×106条或女方年龄偏大时可考虑IVF或ICSI。

Related effect factors of clinical pregnancy outcome after intrauterine insemination

Objective:To explore the relationship between male factors and pregnancy outcome of intrauterine insemination(IUI) by analyzing the clinical data of IUI retrospectively.Methods:The clinical data of the cases who were treated with IUI for 329 cycles in reproductive medical center of He’nan Provincial People’s Hospital from January to December in 2010 were analyzed retrospectively.All the cases were divided into pregnancy group and non-pregnancy group according to the outcome of IUI,the differences of male age,female age,the medical history of infertility,and sperm parameters were compared between the two groups,then the cases were divided into different groups according to the above-mentioned indexes.The differences of pregnancy rates in different groups were compared.Results:There was no significant difference in the male age,female age,and the duration of infertility between pregnancy group and non-pregnancy group(P>0.05);the clinical pregnancy rate in female age>35 years group was significantly lower than that in female age≤35 years group(P<0.05);after treatment,the clinical pregnancy rate in the number of progressive sperm<2×106 group was significantly lower than that in the number of progressive sperm≥2×106 group(P<0.05);there was no significant difference in the clinical pregnancy rate among other groups(P>0.05).Conclusion:Under the circumstance of patent fallopian tubes,the infertile men with the number of progressive sperm≥2×106 after treatment should be treated with IUI as soon as possible,the infertile men with the number of progressive sperm<2×106 after treatment or the older women can consider in vitro fertilization or intracytoplasmic sperm injection.