亮丙瑞林在体外受精-胚胎移植长方案促排卵中的降调节效果观察

目的:观察国产亮丙瑞林在体外受精-胚胎移植(IVF-ET)治疗中长方案超促排卵的降调节效果。方法:回顾性分析2010年4月～2011年5月在青岛大学医学院附属医院生殖医学中心接受IVF-ET/ICSI治疗应用长方案控制性超促排卵148例患者的临床资料。其中32例采用国产亮丙瑞林(亮丙瑞林组)1.2 mg于黄体中期皮下注射进行垂体降调,116例采用达菲林(达菲林组)1.2 mg于黄体中期肌肉注射进行垂体降调。分析比较两组的降调节效果和IVF-ET的结局。结果:两组均达垂体降调标准,月经第2天血清E2、FSH、LH水平比较差异均无统计学意义(均P>0.05);两组获卵数、受精率、优质胚胎数、种植率、临床妊娠率比较差异均无统计学意义(均P>0.05)。结论:在IVF-ET长方案超促排卵中,国产亮丙瑞林1.2 mg黄体中期皮下注射可达到控制性超促排卵的垂体降调节作用,与达菲林具有相同的临床治疗效果。

Observation on the effect of Leuprorelin on down-regulation of long protocol ovulation induction in in vitro fertilization and embryo transfer

Objective:To observe the effect of Leuprorelin on down-regulation of long protocol ovulation induction in in vitro fertilization and embryo transfer(IVF-ET).Methods:The clinical data of 148 patients who had received IVF-ET/intracytoplasmic sperm injection(ICSI) with long protocol for controlled ovarian hyperstimulation(COH) in reproductive medical center of the hospital from April 2010 to May 2011 were analyzed retrospectively.Thirty-two patients were treated with subcutaneous injection of 1.2 mg homemade Leuprorelin(Leuprorelin group) during mid-luteal phase for pituitary down-regulation,while 116 patients were treated with intramuscular injection of 1.2 mg Diphereline(Diphereline group) during mid-luteal phase for pituitary down-regulation.The effects of down-regulation and outcomes of IVF-ET in the two groups were analyzed and compared.Results:The patients in the two groups achieved the standard of pituitary down-regulation,there was no significant difference in the serum levels of estradiol,follicle stimulating hormone(FSH),and luteinizing hormone(LH) between the two groups(P>0.05).There was no significant difference in the number of retrieved oocytes,fertilization rate,the number of high quality embryos,implantation rate,and clinical pregnancy rate between the two groups(P>0.05).Conclusion:Subcutaneous injection of 1.2 mg homemade Leuprorelin during mid-luteal phase can achieve pituitary down-regulation effect of COH in IVF-ET long protocol ovulation induction,the clinical efficacy is the same as Diphereline.