母儿HBeAg的相关性及乙肝疫苗效果的随访研究

目的:探讨乙肝表面抗原阳性孕妇HBeAg与其子代HBeAg、HBsAb的关系。方法:从太原市传染病院收集的表面抗原阳性孕妇及其新生儿共84对母儿作为研究对象,将84例HBsAg阳性孕妇分为HBeAg阳性组和HBeAg阴性组,出生24 h内的新生儿定义为新生儿组,并对其进行随访,随访结果进入婴儿组。收集孕妇分娩前或分娩后24 h内的肘静脉血和出生24 h内的新生儿及其随访时的股静脉血,采用化学发光法检测乙肝标志物。结果:母亲HBeAg阳性组的宫内感染率显著高于HBeAg阴性组。HBeAg阳性组新生儿HBeAg阳性率明显高于HBeAg阴性组(χ2=17.336,P<0.01)。婴儿的HBeAg阳性率与母亲HBeAg无统计学相关性(P>0.05)。母亲、新生儿的HBeAg均与婴儿HBsAb无统计学相关性(P>0.05)。婴儿HBeAg与婴儿表面抗体有统计学差异(χ2=5.687,P<0.05)。结论:母亲HBeAg可能是宫内感染的重要因素。新生儿HBeAg阳性可能与母亲HBeAg阳性有关,婴儿HBsAb与母亲、新生儿的HBeAg无关联,婴儿HBeAg阳性可能会降低婴儿HBsAb水平。

Study on the correlation between maternal HBeAg and infantile HBeAg and follow-up of the effect of hepatitis B vaccine

Objective:To explore the relationship between maternal HBeAg among the pregnant women with positive HBsAg and infantile HBeAg and HBsAb.Methods:A total of 84 pregnant women with positive HBsAg and their neonates were collected from hospital for infectious diseases in Taiyuan city as study objects,then 84 pregnant women with positive HBsAg were divided into HBeAg-positive group and HBeAg-negative group.The neonates within 24 hours after birth were designed as neonate group,then they were followed up,the results of follow-up entered into infant group.The blood samples of anconal vein of pregnant women before delivery and within 24 hours after delivery and the blood samples of femoral vein of the neonates within 24 hours after birth and during follow-up period were collected,chemiluminescence was used to detect hepatitis B markers.Results:Among the pregnant women,the incidence of intrauterine infection in HBeAg-positive group was significantly higher than that in HBeAg-negative group.The positive rate of neonatal HBeAg in HBeAg-positive group was significantly higher than that in HBeAg-negative group(χ2=17.336,P<0.01).There was no correlation between the positive rate of infantile HBeAg and the positive rate of maternal HBeAg(P>0.05).There was no correlation between maternal HBeAg,neonatal HBeAg and infantile HBsAb(P>0.05).There was correlation between infantile HBeAg and infantile HBsAb(χ2=5.687,P<0.05).Conclusion:Maternal HBeAg may be one of the important factors of intrauterine infection.Neonatal HBeAg-positive may be related to maternal HBeAg-positive,there is no correlation between infantile HBsAb and maternal HBeAg,neonatal HBeAg,infantile HBeAg-positive may reduce infantile HBsAb level.