| STAT5基因多态性与哮喘的相关性研究 |
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| 引用本文： | 杜娟,冯清洲,左右,刘晅,叶惠玲.STAT5基因多态性与哮喘的相关性研究[J].中国医师杂志,2011(10):1316-1319. |
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| 作者姓名： | 杜娟 冯清洲 左右 刘晅 叶惠玲 |
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| 作者单位： | 深圳市第七人民医院ICU科,深圳518081 |
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| 基金项目： | 深圳市科技局资助项目（020125） |
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| 摘 要： |
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| 关 键 词： | STATS转录因子／遗传学 多态现象 遗传 哮喘／遗传学 |
Study on the correlation between the polymorphism of STAT5 gene and asthma |
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| DU Juan,FENG Qing-Zhou,ZUO You,LIU Xuan,YE Hui-Ling.Study on the correlation between the polymorphism of STAT5 gene and asthma[J].Journal of Chinese Physician,2011(10):1316-1319. |
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| Authors: | DU Juan FENG Qing-Zhou ZUO You LIU Xuan YE Hui-Ling |
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| Institution: | ( Department of ICU, The Seventh People＇s Hospital of Shenzhen, Shenzhen 518081, China) |
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| Abstract: | Objective To investigate the correlation rs2272087 polymorphism of STATS gene and asthma. Methods The polymerase chain reaction PCR- SBT technique was used to determine rs2272087 palymorphism in asthma and control group. Results The genotype of AA, AG and GG of rs2272087 were 0. 600,0. 412 and 0. 167 in asthma group, and 0. 430,0. 200 , 0. 367 in control group, respectively. The frequency of allele A and G was 0. 903 and 0. 344 in asthma group, and 0. 656 , 0. 970 in control group, respectively. There was significant difference in two groups （ X^2 = 9.40, P 〈 0. 01 ; X^2 = 11.58, P 〈 0. 01 ）. Conclusions The rs2272087 polymorphism of STATS gene may be an important candidate gene for asthma. |
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