| 依布硒啉及苯并异硒唑酮氨基酸衍生物的体外抗肿瘤活性 |
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| 引用本文： | 肖颖歆,刘秀芳,徐汉生. 依布硒啉及苯并异硒唑酮氨基酸衍生物的体外抗肿瘤活性[J]. 微量元素与健康研究, 1996, 0(3) |
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| 作者姓名： | 肖颖歆 刘秀芳 徐汉生 |
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| 作者单位： | 武汉大学化学系 |
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| 摘 要： | 采用ＳＲＢ活细胞染色法，研究了９个新合成的苯并异硒唑酮氨基酸衍生物以及依布硒啉（ｅｂ－ｓｅｌｅｎ）对体外培养的三种不同组织人肿瘤细胞生长的抑制作用。结果表明：这类化合物对人肝癌细胞Ｂｅｌ＿７４０２、结肠癌细胞ＨＣＴ—８和表皮癌细胞Ａ４３１的生长的抑制作用与其化学结构密切相关。所有受试化合物中，以Ｌ—亮氨酸和ＤＬ—丙氨酸衍生物的活性为最佳（ＩＣ５０＜５１μｍｏｌ·Ｌ－１）。
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| 关 键 词： | 硒 依布硒啉 苯并异硒唑酮 氨基酸衍生物 抗肿瘤作用 |
Antitumor Activity of Ebselen and Amino acid Derivatives of Benzisoselenazolone in Vitro |
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| Xiao Yingxin Liu Xiufang Xu Hansheng. Antitumor Activity of Ebselen and Amino acid Derivatives of Benzisoselenazolone in Vitro[J]. Studies of Trace Elements and Health, 1996, 0(3) |
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| Authors: | Xiao Yingxin Liu Xiufang Xu Hansheng |
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| Abstract: | Nien amino acid derivatives of benzisoselenazolone(BISA) as well as ebselen[2-pheny1-1,2-benzisoselenazol-3(2H)-one] were investigated using SRB assay,against three kinds of human tumor cell lines in vitro.They exhibited a fairly apparent structure-inhibition relationship against human liver tumor cell Bel-7402,human colon tumor cell HCT-8 and human epidermal carcinoma cell A431.Among all tested compounds,L-Leucine and DL-Alanine derivatives were the most active compounds(IC 50 <51μ mol/L). |
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| Keywords: | Selenium Ebselen Benzisoselenazolone(BISA) Amino acid derivatives Antitumor activity |
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